PhD Programme in Experimental Medicine and Therapy - Dottorato in Medicina e Terapia Sperimentale

Selected research products

Felicetti F , Aimaretti E , Dal Bello F , Gatti F , Godono A , Saba F , Einaudi G , Collino M , Fagioli F , Aragno M , Brignardello E (2022)
Advanced glycation end products and their related signaling cascades in adult survivors of childhood Hodgkin lymphoma: A possible role in the onset of late complications.
https://iris.unito.it/handle/2318/1856356

Wouters K , Cento A S , Gaens K H , Teunissen M , Scheijen J L J M , Barutta F , Chiazza F , Collotta D , Aragno M , Gruden G , Collino M , Schalkwijk C G , Mastrocola R (2021)
Deletion of RAGE fails to prevent hepatosteatosis in obese mice due to impairment of other AGEs receptors and detoxifying systems.
https://iris.unito.it/handle/2318/1802050

Mastrocola R , Dal Bello F , Cento A S , Gaens K , Collotta D , Aragno M , Medana C , Collino M , Wouters K , Schalkwijk C G (2021)
Altered hepatic sphingolipid metabolism in insulin resistant mice: Role of advanced glycation endproducts.
https://iris.unito.it/handle/2318/1789498

Sansoe G , Aragno M , Wong F (2021)
COVID-19 and Liver Cirrhosis: Focus on the Nonclassical Renin-Angiotensin System and Implications for Therapy.
https://iris.unito.it/handle/2318/1844042

Pasquale Pagliaro, Manuela Aragno, Claudia Penna (2020)
Role of temperature in myocardial ischemic injury and protection by conditioning.
https://iris.unito.it/handle/2318/1737774

Penna C , Andreadou I , Aragno M , Beauloye C , Bertrand L , Lazou A , Falcao-Pires I , Bell R , Zuurbier C J , Pagliaro P , Hausenloy D J (2020)
Effect of hyperglycaemia and diabetes on acute myocardial ischaemia–reperfusion injury and cardioprotection by ischaemic conditioning protocols.
https://iris.unito.it/handle/2318/1737775

Mastrocola R , Collotta D , Gaudioso G , Le Berre M , Cento A S , Ferreira G A , Chiazza F , Verta R , Bertocchi I , Manig F , Hellwig M , Fava F , Cifani C , Aragno M , Henle T , Joshi L , Tuohy K , Collino M (2020)
Effects of exogenous dietary advanced glycation end products on the cross-talk mechanisms linking microbiota to metabolic inflammation.
https://iris.unito.it/handle/2318/1758979

Collotta D , Hull W , Mastrocola R , Chiazza F , Cento A S , Murphy C , Verta R , Alves G F , Gaudioso G , Fava F , Yaqoob M , Aragno M , Tuohy K , Thiemermann C , Collino M (2020)
Baricitinib counteracts metaflammation, thus protecting against diet-induced metabolic abnormalities in mice.
https://iris.unito.it/handle/2318/1758975

Giovanni Sansoè, Manuela Aragno, Florence Wong (2020)
Pathway of hepatic and renal damage through non-classical activation of the renin-angiotensin system in chronic liver disease.
https://iris.unito.it/handle/2318/1793794

Crisafulli, Antonio, Pagliaro, Pasquale, Roberto, Silvana, Cugusi, Lucia, Mercuro, Giuseppe, Lazou, Antigone, Beauloye, Christophe, Bertrand, Luc, Hausenloy, Derek J, Aragno, Manuela, Penna, Claudia (2020)
Diabetic Cardiomyopathy and Ischemic Heart Disease: Prevention and Therapy by Exercise and Conditioning.
https://iris.unito.it/handle/2318/1737773

Francesco Felicetti, Alessia Sofia Cento, Paolo Fornengo, Maurizio Cassader, Raffaella Mastrocola, Fabrizio D’Ascenzo, Fabio Settanni, Andrea Benso, Emanuela Arvat, Massimo Collino, Franca Fagioli, Manuela Aragno, Enrico Brignardello (2020)
Advanced glycation end products and chronic inflammation in adult survivors of childhood leukemia treated with hematopoietic stem cell transplantation.
https://iris.unito.it/handle/2318/1725722

Collotta D, Hull W, Mastrocola R, Chiazza F, Cento AS, Murphy C, Verta R, Ferreira Alves G, Gaudioso G, Fava F, Aragno M, Tuohy K, Thiemermann C, Collino M (2020)
Baricitinib counteracts metaflammation protecting against diet-induced metabolic abnormalities in mice.
https://iris.unito.it/handle/2318/1789502

Mastrocola R, Collotta D, Manig F, Verta R, Le Berre M, Fava F, Gaudioso G, Aragno M, Chiazza F, Hellwig M, Gerlach JQ, Tuohy KM, Joshi L, Henle T, Collino M (2020)
Dietary advanced glycation endproducts in the mechanisms linking proteins glycosylation pattern, microbiota, and metabolic inflammation.
https://iris.unito.it/handle/2318/1789501

Penna, Claudia, Aragno, Manuela, Cento, Alessia Sofia, Femminò, Saveria, Russo, Isabella, Bello, Federica Dal, Chiazza, Fausto, Collotta, Debora, Alves, Gustavo Ferreira, Bertinaria, Massimo, Zicola, Elisa, Mercurio, Valentina, Medana, Claudio, Collino, Massimo, Pagliaro, Pasquale (2020)
Ticagrelor Conditioning Effects Are Not Additive to Cardioprotection Induced by Direct NLRP3 Inflammasome Inhibition: Role of RISK, NLRP3, and Redox Cascades.
https://iris.unito.it/handle/2318/1748513

Cento, AS, Collotta, D, Chiazza, F, Aragno, M, Collino, M, Mastrocola, R (2019)
Inhibition of AGEs by pyridoxamine prevents diet-induced systemic inflammation and skeletal muscle insulin resistance by restoring SphK/S1P3/RhoA signalling.
https://iris.unito.it/handle/2318/1740402

Fausto Chiazza, Saveria Femminò, Debora Collotta, Elisa Zicola, Manuela Aragno, Massimo Bertinaria, Pasquale Pagliaro, Claudia Penna, Massimo Collino (2019)
Do P2Y12 receptor antagonism and NLRP3 inhibition exert additive cardioprotective effects against ischemia/reperfusion injury?
https://iris.unito.it/handle/2318/1755511

Purvis G S D , Collino M , Loiola R A , Baragetti A , Chiazza F , Brovelli M , Sheikh M H , Collotta D , Cento A , Mastrocola R , Aragno M , Cutrin J C , Reutelingsperger C , Grigore L , Catapano A L , Yaqoob M M , Norata G D , Solito E , Thiemermann C (2019)
Identification of Annexina1 as an endogenous regulator of RhoA, and its role in the pathophysiology and experimental therapy of type-2 diabetes.
https://iris.unito.it/handle/2318/1723107

Liberto E, Cordero C, Mastrocola R, Ferrocino I, Chiazza F, Cento AS, Collotta D, Rantsiou K, , , Aragno M, Cocolin L, Bicchi C, Collino M (2018)
SALIVAGE – EU JPI Project The “form” makes the difference: comprehensive two‐dimensional gas chromatography as highly informative fingerprinting tool to study the impact of fructose formulation on mice’s microbiota and its volatile metabolome signatures.
https://iris.unito.it/handle/2318/1678782

Mastrocola, Raffaella, Ferrocino, Ilario, Liberto, Erica, Chiazza, Fausto, Cento, Alessia Sofia, Collotta, Debora, Querio, Giulia, Nigro, Debora, Bitonto, Valeria, Cutrin, Juan Carlos, Rantsiou, Kalliopi, Durante, Mariaconcetta, Masini, Emanuela, Aragno, Manuela, Cordero, Chiara, Cocolin, Luca, Collino, Massimo (2018)
Fructose liquid and solid formulations differently affect gut integrity, microbiota composition and related liver toxicity: a comparative in vivo study.
https://iris.unito.it/handle/2318/1661849

Collotta, Debora, Lucarini, Laura, Chiazza, Fausto, Cento, Alessia Sofia, Durante, Mariaconcetta, Sgambellone, Silvia, Chini, Jacopo, Baratta, Francesca, Aragno, Manuela, Mastrocola, Raffaella, Masini, Emanuela, Collino, Massimo (2018)
Reduced Susceptibility to Sugar-Induced Metabolic Derangements and Impairments of Myocardial Redox Signaling in Mice Chronically Fed with D-Tagatose when Compared to Fructose.
https://iris.unito.it/handle/2318/1683457

Mastrocola, Raffaella, Aragno, Manuela, Alloatti, Giuseppe, Collino, Massimo, Penna, Claudia, Pagliaro, Pasquale (2018)
Metaflammation: tissue-specific alterations of the NLRP3 inflammasome platform.
https://iris.unito.it/handle/2318/1634181

Nigro, Debora, Menotti, Francesca, Cento, Alessia S, Serpe, Loredana, Chiazza, Fausto, Dal Bello, Federica, Romaniello, Francesco, Medana, Claudio, Collino, Massimo, Aragno, Manuela, Mastrocola, Raffaella (2017)
Chronic administration of saturated fats and fructose differently affect SREBP activity resulting in different modulation of Nrf2 and Nlrp3 inflammasome pathways in mice liver.
https://iris.unito.it/handle/2318/1624845

Mastrocola, Raffaella, Aragno, Manuela, Alloatti, Giuseppe, Collino, Massimo, Penna, Claudia, Pagliaro, Pasquale (2017)
Metaflammation: tissue-specific alterations of the NLRP3 inflammasome platform.
https://iris.unito.it/handle/2318/1634181

Aragno, Manuela, Mastrocola, Raffaella (2017)
Dietary sugars and endogenous formation of advanced glycation endproducts: Emerging mechanisms of disease.
https://iris.unito.it/handle/2318/1641649

Sansoè, G, Aragno, M, Mastrocola, R, Parola, M2 (2016)
Dose-dependecy of clonidine's effects in ascitic cirrhotic rats: Comparison with ?1-adrenergic agonist midodrine.
https://iris.unito.it/handle/2318/1521213

Mastrocola, R, Nigro, D, Chiazza, F, Medana, C, Dal Bello, F, Boccuzzi, G, Collino, M, Aragno, M (2016)
Fructose-derived advanced glycation end-products drive lipogenesis and skeletal muscle reprogramming via SREBP-1c dysregulation in mice.
https://iris.unito.it/handle/2318/1542011

Sansoè, Giovanni, Aragno, Manuela, Mastrocola, Raffaella, Mengozzi, Giulio, Parola, Maurizio (2016)
Alpha-2A Adrenoceptor Agonist Guanfacine Restores Diuretic Efficiency in Experimental Cirrhotic Ascites: Comparison with Clonidine.
https://iris.unito.it/handle/2318/1585320

Mastrocola, Raffaella, Nigro, Debora, Cento, Alessia S, Chiazza, Fausto, Collino, Massimo, Aragno, Manuela (2016)
High-fructose intake as risk factor for neurodegeneration: Key role for carboxy methyllysine accumulation in mice hippocampal neurons.
https://iris.unito.it/handle/2318/1554565

Sansoè, Giovanni, Aragno, Manuela, Mastrocola, Raffaella, Mengozzi, Giulio, Novo, Erica, Parola, Maurizio (2016)
Role of Chymase in the Development of Liver Cirrhosis and Its Complications: Experimental and Human Data.
https://iris.unito.it/handle/2318/1598612

Mastrocola, Raffaella, Penna, Claudia, Tullio, Francesca, Femminò, Saveria, Nigro, Debora, Chiazza, Fausto, Serpe, Loredana, Collotta, Debora, Alloatti, Giuseppe, Cocco, Mattia, Bertinaria, Massimo, Pagliaro, Pasquale, Aragno, Manuela, Collino, Massimo (2016)
Pharmacological inhibition of NLRP3 inflammasome attenuates myocardial ischemia/reperfusion injury by activation of RISK and mitochondrial pathways.
https://iris.unito.it/handle/2318/1624808

Mastrocola, Raffaella, Collino, Massimo, Penna, Claudia, Nigro, Debora, Chiazza, Fausto, Fracasso, Veronica, Tullio, Francesca, Alloatti, Giuseppe, Pagliaro, Pasquale, Aragno, Manuela (2016)
Maladaptive Modulations of NLRP3 Inflammasome and Cardioprotective Pathways Are Involved in Diet-Induced Exacerbation of Myocardial Ischemia/Reperfusion Injury in Mice.
https://iris.unito.it/handle/2318/1545358

Sansoe', , Giovanni, Aragno, Manuela, Mastrocola, Raffaella, Parola, Maurizio (2016)
Pathogenesis of Solute-Free Water Retention in Experimental Ascitic Cirrhosis: Is Vasopressin the Only Culprit?
https://iris.unito.it/handle/2318/1528853

Mastrocola, R, Nigro, D, Cento, As, Schiano, G, Chiazza, F, Dal Bello, F, Romaniello, F, Collino, M, Medana, C, Aragno, M (2016)
Pyridoxamine prevents diet-induced insulin resistance through the regulation of ceramide/sphingosine/sphingosine-1-phosphate equilibrium in mice liver.
https://iris.unito.it/handle/2318/1625266

Cento, Alessia Sofia, Nigro, Debora, Chiazza, Fausto, Dal Bello, Federica, Romaniello, Francesco, Collino, Massimo, Medana, Claudio, Aragno, Manuela, Mastrocola, Raffaella (2016)
Advanced Glycation End Products Inhibition Restores Sphingolipid Rheostat in Mice Liver and Prevents Diet-Induced Insulin Resistance.
https://iris.unito.it/handle/2318/1630474

Chiazza, Fausto, Couturier-Maillard, Aurélie, Benetti, Elisa, Mastrocola, Raffaella, Nigro, Debora, Cutrin, Juan C, Serpe, Loredana, Aragno, Manuela, Fantozzi, Roberto, Ryffel, Bernard, Thiemermann, Christoph, Collino, Massimo (2015)
Targeting the NLRP3 inflammasome to reduce diet-induced metabolic abnormalities in mice.
https://iris.unito.it/handle/2318/1550762

de Stefanis, Daniela, Mastrocola, Raffaella, Nigro, Debora, Costelli, Paola, Aragno, Manuela (2015)
Effects of chronic sugar consumption on lipid accumulation and autophagy in the skeletal muscle.
https://iris.unito.it/handle/2318/1528854

Mastrocola R, Collino M, Nigro D, Medana C, Dal Bello F, Chiazza F, Boccuzzi G, Aragno M (2015)
Fructose-derived advanced glycation end-products induce a negative crosstalk between lipogenesis and muscle reprogramming in mice through SREBP-1c.
https://iris.unito.it/handle/2318/1525579

Femminò, S, Chiazza, F, Mastrocola, R, Tullio, F, Penna, C, Nigro, D, Alloatti, G, Cocco, M, Garella, D, Bertinaria, M, Fantozzi, R, Aragno, M, Collino, M, Pagliaro, P (2015)
Is NLRP3 inflammasome a new pharmacological target in myocardial ischemia/reperfusion injury?
https://iris.unito.it/handle/2318/1563302

Tullio, F , Chiazza, F , Mastrocola, R , Penna, C , Nigro, D , Fracasso, V , Alloatti, G , Fantozzi, R , Aragno, M , Collino, M , Pagliaro, P (2015)
Exacerbation of myocardial ischemia/reperfusion injury induced by high-fat-high-fructose (HFHF) diet: Role of NLRP3 inflammasome.
https://iris.unito.it/handle/2318/1563309

Mastrocola R, Collino M, Nigro D, Chiazza F, D', Antona G, Aragno M, Minetto MA (2015)
Accumulation of Advanced Glycation End-Products and Activation of the SCAP/SREBP Lipogenetic Pathway Occur in Diet-Induced Obese Mouse Skeletal Muscle.
https://iris.unito.it/handle/2318/157075

Federica Dal Bello, Valentina Santoro, Manuela Aragno, Raffaella Mastrocola, Claudio Medana, Claudio Baiocchi (2014)
A LIPIDOMIC STUDY OF HIGH-FAT DIET TREATED MICE.
https://iris.unito.it/handle/2318/153711

Sansoe G, Mastrocola R, Aragno M, Parola M (2014)
Dynamics of sodium retention in preascitic cirrhotic rats assessed through parathyroid hormone injection.
https://iris.unito.it/handle/2318/150150

Raffaella Mastrocola, Debora Nigro, Fausto Chiazza, Massimo Collino, Manuela Aragno (2014)
Fructose-Derived Advanced Glycation End-Products Evoke Skeletal Muscle Damage in Mice by Multiple Interference with SCAP-SREBP Pathway.
https://iris.unito.it/handle/2318/150148

M Collino, E Benetti, M Rogazzo, F Chiazza, R Mastrocola, D Nigro, J C Cutrin, M Aragno, R Fantozzi, M A Minetto, C Thiemermann (2014)
A non-erythropoietic peptide derivative of erythropoietin decreases susceptibility to diet-induced insulin resistance in mice.
https://iris.unito.it/handle/2318/154526

Collino M, Mastrocola R, Nigro D, Chiazza F, Aragno M, D', Antona G, Minetto MA (2014)
Variability in myosteatosis and insulin resistance induced by high-fat diet in mouse skeletal muscles.
https://iris.unito.it/handle/2318/149879

Massimo Collino, Elisa Benetti, Mara Rogazzo, Raffaella Mastrocola, Muhammed M Yaqoob, Manuela Aragno, Christoph Thiemermann, Roberto Fantozzi (2013)
Reversal of the deleterious effects of chronic dietary HFCS-55 intake by PPAR- agonism correlates with impaired NLRP3 inflammasome activation.
https://iris.unito.it/handle/2318/119475

M Rogazzo, M Collino, E Benetti, F Chiazza, R Mastrocola, M Minetto, M Aragno, C Thiemermann, R Fantozzi (2013)
Inflammatory signaling and insulin resistance caused by sugar intake: modulation by PPAR-? agonism.
https://iris.unito.it/handle/2318/144597

E Benetti, M Collino, M Rogazzo, F Chiazza, R Mastrocola, M Aragno, M Minetto, C Thiemermann, R Fantozzi (2013)
A nonerythropoietic peptide analog of erythropoietin decreases susceptibility to diet-induced insulin resistance.
https://iris.unito.it/handle/2318/144592

Benetti E, Mastrocola R, Rogazzo M, Chiazza F, Aragno M, Fantozzi R, Collino M, Minetto MA (2013)
High Sugar Intake and Development of Skeletal Muscle Insulin Resistance and Inflammation in Mice: A Protective Role for PPAR- ? Agonism.
https://iris.unito.it/handle/2318/138588

Mastrocola R, Collino M, Rogazzo M, Medana C, Nigro D, Boccuzzi G, Aragno M (2013)
Advanced glycation end-products promote hepatosteatosis by interfering with SCAP-SREBP pathway in fructose drinking mice.
https://iris.unito.it/handle/2318/138695

Gaia S, Olivero A, Smedile A, Ruella M, Abate ML, Fadda M, Rolle E, Omdé P, Bondesan P, Passera r, Risso A, Aragno M, Marzano A, Ciancio A, Rizzetto M, Tarella C (2013)
Multiple courses of G-CSF in patients with decompensated cirrosi: consistent mobilization of immature cells ex pressing hepatocyte markers and exploratory clinical evaluation.
https://iris.unito.it/handle/2318/154133

Giovanni Sansoè, Manuela Aragno, Raffaella Mastrocola, Claudia Paternostro, Maurizio Parola (2013)
Calcium receptors located in fibrotic septa: a new target to reduce portal pressure in liver cirrhosis.
https://iris.unito.it/handle/2318/130145

C Medana, P Calza, V Giancotti, F Dal Bello, M Aragno, C Baiocchi (2013)
Study of the photocatalytic transformation of synephrine: a biogenic amine relevant in anti-doping analysis.
https://iris.unito.it/handle/2318/141890

Guglielmotto M, Aragno M, Tamagno E, Vercellinatto I, Visentin S, Medana C, Catalano MG, Smith MA, Perry G, Danni O, Boccuzzi G, Tabaton M (2012)
AGEs/RAGE complex upregulates BACE1 via NF-kappaB pathway activation.
https://iris.unito.it/handle/2318/81738

Sansoè G, Aragno M, Mastrocola R, Mengozzi G, Novo E, Smedile A, Parola M, Rizzetto M (2012)
Inhibition of chymase-dependent production of kidney angiotensin II improves renal sodium handling and prevents ascites in experimental liver cirrhosis.
https://iris.unito.it/handle/2318/99931

Courses

• Fisiopatologia generale, immunologia, patologia generale - D.M. 270/04 (MED3035A)
  Corso di Laurea in Infermieristica - Sede TO4 Ivrea
• PATOLOGIA E DIAGNOSTICA DI LABORATORIO (MED3035)
  Corso di Laurea in Infermieristica - Sede TO4 Ivrea
• PATOLOGIA E DIAGNOSTICA DI LABORATORIO (MED3035)
  Corso di laurea in Infermieristica - Aosta
• Patologia generale (canale A) (SME0723)
  Laurea Magistrale in Medicina e Chirurgia - sede di Torino
• Patologia generale (canale B) (SME0723)
  Laurea Magistrale in Medicina e Chirurgia - sede di Torino
• Patologia generale (canale C) (SME0723)
  Laurea Magistrale in Medicina e Chirurgia - sede di Torino
• Patologia generale (canale D) (SME0723)
  Laurea Magistrale in Medicina e Chirurgia - sede di Torino
• Patologia, immunologia e fisiopatologia generale (MED/04)
  Corso di laurea in Infermieristica - Aosta
• Tirocinio professionalizzante patologia generale (SME0927)
  Laurea Magistrale in Medicina e Chirurgia - sede di Torino

Research topics

Per maggiori dettagli è possibile consultare la pagina del Docente sul sito del Dottorato in Medicina e Terapia Sperimentale

Research groups

• AGEs and Inflammation in Metabolic Disorders

Activities in agenda

See my calendar

Academic bodies

• Consiglio di Dipartimento - Dipartimento di Scienze Cliniche e Biologiche

• Commissione permanente attività didattiche elettive (ADE) (a.a. 2021/2022 – 2022/2023)

• Commissione permanente attività didattiche elettive (ADE) (a.a. 2021/2022 – 2022/2023)
• Commissione permanente per la valutazione delle domande del personale del S.S.N. ed Universitario equiparato per gli affidamenti di incarichi di insegnamento - A.A. 2020/21 – 2021/2022
• Componente docenti della Commissione permanente per la definizione e/o integrazione degli elenchi dei collaboratori alla didattica (da A.A. 2019/2020 – A.A. 2023/2024)

Office hours

Tramite contatto telefonico 011-6707783 o e-mail: manuela.aragno@unito.it