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20-21 Cholesterol and its metabolites in age-related diseases: Alzheimer’s disease and atherosclerosis

Oggetto:

20-21 Cholesterol and its metabolites in age-related diseases: Alzheimer’s disease and atherosclerosis

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Anno accademico 2020/2021

Docenti
Prof.ssa Paola Francesca Gamba (Titolare del corso)
Dott.ssa Gabriella Testa (Titolare del corso)
Prof.ssa Gabriella Marisa Leonarduzzi (Titolare del corso)
Corso di studio
Ciclo XXXII
Ciclo XXXIII
Ciclo XXXIV
Ciclo XXXV
Periodo
Giornaliero
Tipologia
Seminario
Crediti/Valenza
1
SSD attività didattica
MED/04 - patologia generale
Erogazione
A distanza
Lingua
Inglese
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Sommario insegnamento

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Obiettivi formativi

The aim of these activities is to offer PhD students in Experimental Medicine and Therapy an up-date on current knowledge about cholesterol homeostasis and the involvement of cholesterol oxidation products, known as oxysterols, in the pathogenesis of two major chronic inflammatory human diseases, Alzheimer’s disease and atherosclerosis.

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Programma

Cholesterol oxidation products, known as oxysterols, are potentially involved in the pathogenesis of major chronic human diseases, including Alzheimer's disease (AD) and atherosclerosis. It is well documented that altered cholesterol metabolism in the brain and hypercholesterolemia, together with oxidative stress and neuroinflammation, significantly contribute to AD pathogenesis. Moreover, oxidative stress and inflammation are associated to hypercholesterolemia and they have been recognized as partners in crime in bringing about atheroma development and destabilization due to atherosclerosis. The involvement of oxysterols in AD pathogenesis and in atherosclerotic plaque instability, and the analysis of such products in the plasma, in the brain and in atheromas may contribute to clarifying the role of cholesterol metabolism in these chronic diseases; ultimately, it may be helpful in developing therapeutic strategies to prevent or slow their development.

 

The activity will be structured in 3 lectures:

  1. Controversial role of oxysterols in Alzheimer’s disease pathogenesis (Dr Paola Gamba/Dr Gabriella Testa, University of Turin) – 2 hours
  2. Oxidized lipids in atherosclerotic plaque instability (Dr Paola Gamba/Dr Paola Gamba) – 1 hour
  3. Use of antioxidants to counteract the pathological effects of oxysterols (Dr Gabriella Testa, University of Turin) – 1 hours
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Modalità di verifica dell'apprendimento

Final test examination

Testi consigliati e bibliografia

Oggetto:

  1. Gamba P, Staurenghi E, Testa G, Giannelli S, Sottero B, Leonarduzzi G. A Crosstalk Between Brain Cholesterol Oxidation and Glucose Metabolism in Alzheimer's Disease. Front Neurosci. 2019, 13:556.
  2. Sottero B, Leonarduzzi G, Testa G, Gargiulo S, Poli G, Biasi F. Lipid oxidation derived aldehydes and oxysterols between health and disease. Eur J Lipid Sci Technol. 2018: 1-16.
  3. Gargiulo S, Gamba P, Testa G, Leonarduzzi G, Poli G. The role of oxysterols in vascular
    ageing. J Physiol. 2016, 594(8):2095-113.
  4. Gamba P, Testa G, Gargiulo S, Staurenghi E, Poli G, Leonarduzzi G. Oxidized cholesterol as
    the driving force behind the development of Alzheimer's disease. Front Aging Neurosci. 2015, 7:119.


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Note

  • 29 October 2020
  • 05 Novembre 2020
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