Dottorato in Medicina e Terapia Sperimentale: Metabolic pathways associated with oxysterol-induced cytotoxicity: oxidation, inflammation, phospholipidosis and cell death (apoptosis and autophagy)

Academic year 2013/2014

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Prof. Gérard LIZARD

Université de Bourgogne

Directeur de l'Equipe d'Accueil Bio-PeroxIL (EA7270)

Biochimie du peroxysome, inflammation et métabolisme lipidique

Faculté des Sciences Gabriel

6, Bd Gabriel

21000 Dijon France

'Metabolic pathways associated with oxysterol-induced cytotoxicity:

oxidation, inflammation, phospholipidosis and cell death

(apoptosis and autophagy)'

The group managed by Gérard Lizard, inside the team Bio-peroxIL (Director: Gérard Lizard), is interested in studying i) the incidence of peroxisomal deficiencies on neuronal cells (oligodendrocytes, astrocytes, and microglial cells) and ii) the impact of very long chain fatty acids on neurons in the field of peroxisomal leukodystrophies and Alzheimer’s disease, respectively. The consequences of peroxisomal defiencies on oxidative stress and inflammation (cytokinic and non cytokinic) are studied. In this context, the part taken by oxysterols, mainly those produced by autoxidation, is investigated. We are also interested by the biological activities of phytosterols present in argan oil (spinasterol, schotenol) and by their ability to prevent cell death, oxidative and/or inflammatory disorders. In various neurological diseases (peroxisomal leukodystrophies, multiple sclerosis, Alzheimer’s disease), we attempt to define whether some oxysterols can constitute potential biomarkers.

More details on the activities of Bio-peroxIL laboratory are given on the website:

http://bioperoxil.u-bourgogne.fr/

Gerard Lizard (PhD; Prof.), gerard.lizard@u-bourgogne.fr

Note

Scuola di Medicina San Luigi Gonzaga

Regione Gonzole 10

ORBASSANO

Polo Didattico, aula ARANCIO

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