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Doctoral school

PhD Programme in Experimental Medicine and Therapy - Dottorato in Medicina e Terapia Sperimentale

Logo di PhD Programme in Experimental Medicine and Therapy - Dottorato in Medicina e Terapia Sperimentale

Dott.ssa Antonella Nai

  • Phd: 24th cycle
  • Matriculation number: 280731

Contacts

Supervisor


Curriculum vitae

Curriculum Vitae

Research activities

Regulation of iron metabolism

  1.  Nai A., Pagani A., Silvestri L., Campostrini N., Corbella M., Girelli D., Traglia M., Toniolo D. and Camaschella C. TMPRSS6 rs855791 modulates hepcidin transcription in vitro and serum hepcidin levels in normal individuals. Blood. 118(16):4459-62 (2011)

 

  1. Pagani A., Nai A., Corna G., Bosurgi L., Rovere-Querini P., Camaschella C. and Silvestri L., Low hepcidin accounts for the proinflammatory status associated with iron deficiency. Blood. 118(3):736-46 (2011)

 

  1. Poli M., Girelli D., Campostrini N., Maccarinelli F., Finazzi D., Luscieti S., Nai A. and Arosio P., Heparin: a potent inhibitor of hepcidin expression in vitro and in vivo. Blood. 117(3):997-1004 (2011)

 

  1. Nai A., Pagani A., Silvestri L. and Camaschella C., Increased susceptibility to iron deficiency of Tmprss6-haploinsufficient mice. Blood. 116(5):851-2 (2010)

 

  1. De Falco L., Totaro F., Nai A., Pagani A., Girelli D., Silvestri L.,  Piscopo C., Campostrini N., Dufour C., Al Manjomi F., Minkov M., Van Vuurden DG, Feliu A., Kattamis A., Camaschella C.and Iolascon A. Novel TMPRSS6 mutations associated with iron-refractory iron deficiency anemia (IRIDA). Hum Mutat. 31(5):E1390-405 (2010)

 

  1. Camaschella C., Nai A., Pagani A., Silvestri L. Matriptase-2, a novel suppressor of hepcidin. American Socierty of Hematology 2009, Program Book.

 

  1. Silvestri L., Guillem F., Pagani A., Nai A., Oudin C., Silva M., Toutain F., Kannengiesser C., Beaumont C., Camaschella C. and Grandchamp B. Molecular mechanisms of the defective hepcidin inhibition in TMPRSS6 mutations associated  with iron-refractory iron deficiency anemia. Blood, 113 (22): 5605-08 (2009).

 

  1. Silvestri L., Pagani A., Nai A., De Domenico I., Kaplan J. and Camaschella C. The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin. Cell Met., 8 (6): 502-11 (2008).

 

  1. Pagani A., Silvestri L., Nai A., Camaschella C. Hemojuvelin N-terminal mutants reach the plasma membrane but do not activate the hepcidin response. Haematologica, 93 (10): 1466-72 (2008).

 

  1. Eva C., Mele P., Collura D., Nai A., Pisu MG., Serra M. and Biggio G. Modulation of neuropeptide Y and Y1 receptor expression in the amygdala by fluctuations in the brain content of neuroactive steroids during ethanol drinking discontinuation in Y1R/LacZ transgenic mice. J. Neurochem., 104(4):1043-54 (2008).

  1. Nai A., Pagani A., Lidonnici MR., Mandelli G., Silvestri L., Ferrari G. and Camaschella C Tmprss6 haploinsufficiency ameliorates the phenotype of β-thalassemic Hbbth3/+ mouse model. European Iron Club. Louvain-la-Neuve, Belgium, September 8-10, 2011

 

  1.  Nai A., Pagani A., Silvestri L. and Camaschella C. Tmprss6 haploinsufficient mice have an increased susceptibility to develop iron deficiency. Selected for oral communication. European Iron Club, Njimegen, Nedherland, September 15-17, 2010

 

  1. Silvestri L., Guillem F., Pagani A., Nai A., De Falco L., Iolascon A., Beaumont C., Grandchamp B. and Camaschella C. Mechanisms of hepcidin inhibition by novel TMPRSS6 (Matriptase-2) mutations associated with IRIDA. Selected for oral communication. International Bioiron Society Meeting, Porto, Portugal, June 7-11, 2009

 

  1. Silvestri L., Pagani A., Nai A., Guillem F., De Falco G., Iolascon A., Beaument C., Grandchamp B. and Camaschella C. Molecular mechanisms of genetic Iron Refractory Iron Deficiency Anemia (IRIDA). Selected for oral communication. European Association for Red Cell Research, Triuggio (MI), Italy, 24-27 April, 2009

 

  1. Silvestri L., Pagani A., Nai A., De Domenico I., Kaplan J. and Camaschella C. Hemochromatosis: from genes to clinics and back. Best poster award, Telethon Scientific Convention, Riva del Garda (TN), Italy, March 9-11, 2009.

 

  1. Silvestri L., Pagani A., Nai A., De Domenico I., Kaplan J. and Camaschella C. Mechanisms of hepcidin inhibition by wild type and mutants TMPRSS6/MT2. Workshop on iron overload, Annapolis, MD, October 27-28, 2008

 

  1. Nai A., Pagani A., Camaschella C. and Silvestri L., Neogenin regulates soluble hemojuvelin production through modulation of furin. Best poster award, European Iron Club meeting 2008, St. Gallen, Switzerland, September 17-19, 2008

 

  1. Pagani A., Silvestri L., Nai A., Camaschella C. N-terminal hemojuvelin mutants do not activate hepcidin response and are delayed in plasma membrane export. European Iron Club, St. Gallen, Switzerland, September 17-19, 2008

 

  1. Silvestri L., Pagani A., Nai A., De Domeico I., Kaplan J. and Camaschella C. Matriptase-2 (TMPRSS6) inhibits hepcidin by cleaving membrane hemojuvelin. Oral communication. European Iron Club, St. Gallen, Switzerland, September 17-19, 2008

 

  1. Mele P., Nai A., Collura D., Serra M., Pisu M.G., Eva C. and Biggio G., Role of neurosteroids in the modulation of NPY/Y1R neurotransmission during ethanol and GHB withdrawal. ECNP Workshop on Neuropsycopharmacology for Young Scientists in Europe, Nice, France, March 6-9, 2008.

Last update: 05/11/2013 13:32
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