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Experimental Medicine and Therapy - Personalisation of therapies
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Experimental Medicine and Therapy - Personalisation of therapies
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Academic year 2024/2025
- Teacher
- Antonio D' Avolio (Titolare del corso)
- Year
- 3rd year
- Teaching period
- Da definire
- Language
- Inglese
- Attendance
- Facoltativa
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Sommario del corso
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Course objectives
The course aims to provide the student with knowledge of the rational basis of personalising drug therapy and the clinical applications of Therapeutic Drug Monitoring and Pharmacogenetics. At the end of the course, the student will be able to assess and describe how to personalise a drug therapy and to envisage its possible therapeutic uses, taking into account its structure, mechanism of action, kinetics and the relationship between pharmacological and toxicological effects in relation to the patient's genetics.
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Results of learning outcomes
At the end of the course, the student will have to demonstrate knowledge and understanding of the fundamental mechanisms governing pharmacogenetics, pharmacokinetics, pharmacodynamics, the main genetic and non-genetic factors responsible for variability in drug response, and the mode of action to tailor therapy for maximum response while minimising toxic effects.
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Program
- Pharmacokinetics and Therapeutic Drug Monitoring
- Pharmacogenetics
- TDM in oncology
- TDM of monoclonal drug
- TDM of antipsychotic
- Personalisation of therapies in infectious diseases
- The liquid biopsis
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Course delivery
To achieve the learning objectives of this teaching, audio-video lessons uploaded on moodle are used.
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Learning assessment methods
Learning will be tested at the end of the lectures by means of an on-line test on moodle. The final assessment will be expressed in terms of suitability or otherwise.
Suggested readings and bibliography
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Students will be provided with the material used for the lectures (audio-slides). This material serves as a support or guide for studying and preparing for the examination and does not replace the textbook.
Recommanded texts
- FARMACOLOGIA GENERALE E CLINICA. X Edizione 2017 condotta sulla XIII Edizione americana di B.G. Katzung e A.J. Trevor a cura del Prof. P. Preziosi. Casa Editrice Piccin Nuova Libraria, Padova.
- GOODMAN & GILMAN - LE BASI FARMACOLOGICHE DELLA TERAPIA. Edizione 2019 condotta sulla XIII Edizione americana di L.L. Brunton, R. Hilal-Dandan e B.C. Knollmann a cura dei Prof. F. Celotti, P. Giusti, A. Sala e V. Locatelli. Casa Editrice Zanichelli, Bologna.
Site for in-depth bibliography: www.ncbi.nlm.nih.gov/pubmed/
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Notes
Courses can be taken when the student has time, as the audio-slides are uploaded on moodle.
- Enroll
- Open
- Enrollment opening date
- 22/11/2024 at 12:00
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