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Cholesterol and its metabolites in Alzheimer’s disease: their action on brain cells and signaling pathways

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Academic year 2020/2021

Teaching staff
Prof.ssa Gabriella Marisa Leonarduzzi (Titolare del corso)
Prof.ssa Paola Francesca Gamba (Titolare del corso)
Dott.ssa Gabriella Testa (Titolare del corso)
Teaching period
Giornaliero
Type
Seminario
Credits/Recognition
1
Course disciplinary sector (SSD)
MED/04 - experimental medicine and pathophysiology
Delivery
Tradizionale
Language
Inglese
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Sommario del corso

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Course objectives

The aim of these activities is to offer PhD students in Experimental Medicine and Therapy an up-date on current knowledge about cholesterol homeostasis and the involvement of cholesterol oxidation products in the pathogenesis of AD.

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Course delivery

The activity will be structured in 3 lectures:

1) Controversial role of oxysterols in Alzheimer’s disease pathogenesis (Dr Paola Gamba/Dr Gabriella Testa, University of Turin) – 2 hours

2) Role of astrocyte reactivity in Alzheimer’s disease progression (Dr Gabriella Leonarduzzi/Dr Erica Staurenghi) – 2 hours

3) Use of antioxidants or other strategies to counteract the pathological effects of oxysterols (Dr Gabriella Testa, University of Turin) – 1 hours

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Learning assessment methods

Learning assessment methods

Final test examination.

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Program

Cholesterol oxidation products, known as oxysterols, are potentially involved in the pathogenesis of major chronic human diseases, including Alzheimer's disease (AD).

It is well documented that altered cholesterol metabolism in the brain and hypercholesterolemia, together with oxidative stress and neuroinflammation, significantly contribute to AD pathogenesis.

The analysis of oxysterols in plasma and brain may contribute to clarifying the role of cholesterol metabolism in AD pathogenesis; in particular, it is important to highlight their effects on brain cells (neurons, astrocytes,…) and on the modulation of certain signaling pathways that can act on cell-death or cell survival. Deepening these aspects could be useful for developing new therapeutic strategies to prevent or slow AD progression.

Suggested readings and bibliography

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Note

Suggested readings

  1. Gamba P, Giannelli S, Staurenghi E, Testa G, Sottero B, Biasi F, Poli G, Leonarduzzi G. The controversial role of 24-S-hydroxycholesterol in Alzheimer’s disease. Antioxidants 2021, 10:740.
  2. Gamba P, Staurenghi E, Testa G, Giannelli S, Sottero B, Leonarduzzi G. A Crosstalk Between Brain Cholesterol Oxidation and Glucose Metabolism in Alzheimer's Disease. Front Neurosci. 2019, 13:556.
  3. Sottero B, Leonarduzzi G, Testa G, Gargiulo S, Poli G, Biasi F. Lipid oxidation derived aldehydes and oxysterols between health and disease. Eur J Lipid Sci Technol. 2018: 1-16.
  4. Gamba P, Testa G, Gargiulo S, Staurenghi E, Poli G, Leonarduzzi G. Oxidized cholesterol as the driving force behind the development of Alzheimer's disease. Front Aging Neurosci. 2015, 7:119.
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