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The impact of latent/chronic infections on neurodegeneration and organ damage
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Academic year 2022/2023
- Teacher
- Prof. Andrea Calcagno (Titolare del corso)
- Degree course
- Ciclo XXXV
Ciclo XXXVI
Ciclo XXXVII - Teaching period
- Giornaliero
- Type
- Course Seminario
- Credits/Recognition
- 1
- Course disciplinary sector (SSD)
- MED/17 - infectious diseases
- Language
- Inglese
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Sommario del corso
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Course objectives
The main objectives of the course are:
- Provide students with epidemiological data on the association between viral/parasitic infections and chronic organ damage
- Discuss the pathogenesis of these changes and the potential biomarkers for assessing organ damage
- Assess potential treatments that, by affecting microbe replication or biomass, may have an effect on tissue pathology
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Course delivery
Two lectures will be provided with one focusing on the central nervous system and the other one on several other organs and tissues. At the beginning of each class an online quiz will be provided in order to test pre-activity knowledge. Approximately 20% of the time will be devoted to group discussion.
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Learning assessment methods
After the end of the course students will be asked to prepare a brief (one-page max) study draft developing a research project on one of the discussed topics.
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Program
This course programme includes two formal lectures and pre-reading materials. The focus is on the interplay between infections and long-term/chronic consequences in the central nervous system (mostly focusing on neurodegeneration) and in several organs and tissues (assessing fibrosis and potential therapeutic options). This will include, among others, available data on herpesviruses, HIV, Toxoplasma, HCV, HBV, SARS-CoV-2 and Schistosoma.
Suggested readings and bibliography
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- Zhu X, Raina AK, Perry G, Smith MA. Alzheimer's disease: the two-hit hypothesis. Lancet Neurol. 2004 Apr;3(4):219-26. doi: 10.1016/S1474-4422(04)00707-0. PMID: 15039034.
- Ortiz-Guerrero G, Gonzalez-Reyes RE, de-la-Torre A, Medina-Rincón G, Nava-Mesa MO. Pathophysiological Mechanisms of Cognitive Impairment and Neurodegeneration by Toxoplasma gondii Infection. Brain Sci. 2020 Jun 12;10(6):369. doi: 10.3390/brainsci10060369. PMID: 32545619; PMCID: PMC7349234.
- Roehlen N, Crouchet E, Baumert TF. Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives. Cells. 2020 Apr 3;9(4):875. doi: 10.3390/cells9040875. PMID: 32260126; PMCID: PMC7226751.
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Note
Strongly recommended course for XXXV/XXXVI/XXXVII Cycle Second-Year students
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