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Doctoral school

PhD Programme in Experimental Medicine and Therapy - Dottorato in Medicina e Terapia Sperimentale

Logo di PhD Programme in Experimental Medicine and Therapy - Dottorato in Medicina e Terapia Sperimentale

Dott. Alberto Rocci

  • Phd: 28th cycle
  • Matriculation number: 321523

Contacts

Supervisor

Gabriella Marisa Leonarduzzi

Research activities

My interest is focus on onco-haematology, in particular on multiple myeloma. Beside clinical activity I am interest in translational research in the field of multiple myeloma:

- microRNA deregulation 

- Minimal residual disease 

- New non-chemotherapeutic drugs in multiple myeloma

- Early clinical trials in multiple myeloma

- High-dose chemotherapy followed by autologous stem cell transplantation in hematological malignancies

 

 

 

  1. Bonanno G, Mariotti A, Procoli A, Folgiero V, Natale D, De Rosa L, Majolino I, Novarese L, Rocci A, Gambella M, Ciciarello M, Scambia G, Palumbo A, Locatelli F, De Cristofaro R, Rutella S. Indoleamine 2,3-dioxygenase 1 (IDO1) activity correlates with immune system abnormalities in multiple myeloma. J Transl Med. 2012 Dec 11;10:247.
  2. Falco P, Cavallo F, Larocca A, Rossi D, Guglielmelli T, Rocci A, Grasso M, Siez ML, De Paoli L, Oliva S, Molica S, Mina R, Gay F, Benevolo G, Musto P, Omedè P, Freilone R, Bringhen S, Carella AM, Gaidano G, Boccadoro M, Palumbo A. Lenalidomide-prednisone induction followed by lenalidomide-melphalan-prednisone consolidation and lenalidomide-prednisone maintenance in newly diagnosed elderly unfit myeloma patients. Leukemia. 2012 Oct 12. 
  3. Lobetti-Bodoni C, Ferrero D, Genuardi E, Passera R, Bernocco E, Sia D, Grignani G, Crisà E, Monitillo L, Rocci A, Drandi D, Giai V, Zanni M, Boi M, Isaia G, Barbero D, Lunghi M, Abruzzese E, Radaelli F, Pini M, Pregno P, Carlo-Stella C, Gaidano G, Boccadoro M, Ladetto M. Telomere loss in Philadelphia-negative hematopoiesis after successful treatment of chronic myeloid leukemia: Evidence for premature aging of the myeloid compartment. Mech Ageing Dev. 2012 Jul;133(7):479-88 
  4. Ross F, Avet-Loiseau H, Ameye G, Gutierrez NC, Liebisch P, O' Connor S, Dalva K, Fabris S, Testi AM, Jarosova M, Collin A, Kerndrup G, Kuglik P, Ladon D, Bernasconi P, Maes B, Zemanova Z, Michalova K, Michaux L, Neben K, Hermansen NE, Rack K, Rocci A, Protheroe R, Chiecchio L, Poirel HA, Sonneveld P, Nyegaard M, Johnsen HE. Report from the european myeloma network on interphase FISH in multiple myeloma and related disorders. Haematologica. 2012 Aug;97(8):1272-7.
  5. Agnelli L, Storti P, Todoerti K, Sammarelli G, Dalla Palma B, Bolzoni M, Rocci A, Piazza F, Semenzato G, Palumbo A, Neri A, Giuliani N. Overexpression of HOXB7 and homeobox genes characterizes multiple myeloma patients lacking the major primary immunoglobulin heavy chain locus translocations. Am J Hematol. 2011 Dec;86(12):E64-6.
  6. Pichiorri F, Suh SS, Rocci A, De Luca L, Taccioli C, Santhanam R, Zhou W, Benson DM Jr, Hofmainster C, Alder H, Garofalo M, Di Leva G, Volinia S, Lin HJ, Perrotti D, Kuehl M, Aqeilan RI, Palumbo A, Croce CM. Downregulation of p53-inducible microRNAs 192, 194, and 215 impairs the p53/MDM2 autoregulatory loop in multiple myeloma development. Cancer Cell. 2010 Oct 19;18(4):367-81 
  7. Engelhardt M, Udi J, Kleber M, Spencer A, Rocci A, Knop S, Bruno B, Bringhen S, Pérez-Simón JA, Zweegman S, Driessen C, Patriarca F, Gramatzki M, Terpos E, Sezer O, Kropff M, Straka C, Johnsen HE, Waage A, Boegsted M, Lokhorst H, Hájek R, Morgan G, Boccadoro M, Ludwig H, Cavo M, Polliack A, Sonneveld P, Einsele H, Palumbo A. European Myeloma Network: the 3rd Trialist Forum Consensus Statement from the European experts meeting on multiple myeloma. Leukemia & Lymphoma. 2010 Nov;51(11):2006-2011
  8. 8.     Aspesi A, Vallero S, Rocci A, Pavesi E, Lanciotti M, Ramenghi U, Dianzani I. Compound heterozygosity for two new TERT mutations in a patient with aplastic anemia. Pediatric Blood & Cancer. 2010 Sep;55(3):550-3.
  9. Giuliani N, Lisignoli G, Novara F, Storti P, Zaffaroni N, Villa R, Sammarelli G, Agnelli L, Todoerti K, Bernardo ME, Manferdini C, Colla S, Abeltino M, Bolzoni M, Rocci A, Gabusi E, Palumbo A, Zuffardi O, Neri A, Rizzoli V. Bone osteoblastic and mesenchymal stromal cells lack primarily tumoral features in multiple myeloma patients. Leukemia 2010 2010 Jul;24(7):1368-70
  10. Ruella M, Rocci A, Ricca I, Carniti C, Lobetti Bodoni C, Ladetto M, Caracciolo D, Boccadoro M, Carlo-Stella C, Corradini P, Tarella C. Comparative assessment of telomere length before and after hematopoietic SCT : role of grafted cells in determining post-transplant telomere status. Bone Marrow Transplantation. 2010 Mar;45(3):505-512
  11. Pavesi E, Avondo F, Aspesi A, Quarello P, Rocci A, Vimercati C, Pigullo S, Dufour C, Ramenghi U, Dianzani I. Analysis of telomeres in peripheral blood cells from patients with bone marrow failure. Pediatric Blood & Cancer. 2009 Sep;53(3):411-6.
  12. Rossi D, Lobetti Bodoni C, Genuardi E, Monitillo L, Drandi D, Cerri M, Deambrogi C, Ricca I, Rocci A, Ferrero S, Bernocco E, Capello D, De Paoli L, Bergui L, Boi M, Omedè P, Massaia M, Tarella C, Passera R, Boccadoro M, Gaidano G, Ladetto M Telomere length is an independent predictor of survival, treatment requirement and Richter's syndrome transformation in chronic lymphocytic leukemia. Leukemia. 2009 Jun;23(6):1062-72.
  13. Rocci A, Ricca I, Dellacasa C, Longoni P, Compagno M, Francese R, Lobetti Bodoni C, Manzini P, Caracciolo D, Boccadoro M, Ferrero D, Ladetto M, Carlo-Stella C, Tarella C. Long-term lymphoma survivors following High-Dose chemotherapy and autograft: evidence of permanent telomere shortening in myeloid cells, associated with marked reduction of bone marrow hematopoietic stem cell reservoire. Experimental Hematology 2007 Apr;35(4):673-81
  14. Ricca I, Rocci A, Drandi D, Roberto F, Compagno M, Lobetti Bodoni C, De Marco F, Astolfi M, Monitillo L, Vallet S, Calvi R, Ficara F, Omedè P, Rosato R, Gallamini A, Marinone C, Bergui L, Boccadoro M, Tarella C, Ladetto M. Telomere length identifies two different prognostic subgroups among VH-unmutated B-cell chronic lymphocytic leukemia patients. Leukemia. 2007 Apr;21(4):697-705 
  15. Ladetto M, Mantoan B, De Marco F, Drandi D, Aguzzi C, Astolfi M, Vallet S, Ricca I, Dell’Aquila M, Pagliano G, Monitillo L, Pollio B, Santo L, Cristiano C, Rocci A, Francese R, Lobetti Bodoni C, Borchiellini A, Schinco P, Boccadoro M, Tarella C. Cells carrying nonlymphoma-associated bcl-2/IgH rearrangements (NLABR) are phenotypically related to follicular lymphoma and can establish as long-term persisting clonal populations. Experimental Hematology 2006 Dec;34(12).1680-86
  16. Ladetto M, Vallet S, Trojan A, Dell’Aquila M, Monitillo L, Rosato R, Santo L, Drandi D,  Bertola A, Falco P, Cavallo F, Ricca I, De Marco F, Mantoan B, Bode-Lesniewska B, Pagliano G, Francese R, Rocci A, Astolfi M, Compagno M, Mariani S, Godio L, Marino L, Ruggeri M, Omedè P, Palumbo A, Boccadoro M. Cyclooxygenase-2 (COX-2) is frequently expressed in multiple myeloma and is an independent predictor of poor outcome. Blood 2005 Jun 15;105(12):4784-91
  17. Ricca I, Compagno M, Ladetto M, Rocci A, Dell’Aquila M, Omedè P, De Marco F, D’Antico S, Caracciolo D, Ferrero D, Carlo-Stella C, Tarella C. Two consecutive courses of peripheral blood progenitor cell (PBPC) mobilization induce marked telomere length shortening. Leukemia 2005 Apr;19(4):644-51
  18. Ladetto M, Compagno M, Ricca I, Pagano M, Rocci A, Astolfi M, Drandi D, Francia di Celle P, Dell’Aquila M, Mantoan B, Vallet S, Pagliano G, De Marco F, Francese R, Santo L, Cuttica A, Marinone C, Boccadoro M, Tarella C. Telomere length correlates with histopathogenesis according to the germinal center in mature B-cell lymphoproliferative disorders. Blood. 2004 Jun 15;103(12):4644-9
  19. Ladetto M, Mantoan B, Ricca I, Astolfi M, Drandi D, Compagno M, Vallet S, Dell’Aquila M, Alfarano A, Rossatto P, Rocci A, Vitolo U, Corradini P, Boccadoro M, Tarella C. Recurrence of Bcl-2/IgH PCR positivity following a prolonged  molecular remission can be unrelated to the original follicular lymphoma clone. Experimental Hematology. 2003 Sep;13(9):784-788



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