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Dott.ssa Gabriella Testa

  • Dottorato: 24° ciclo
  • Matricola: 712897

Contatti

Tutore

Prof.ssa Gabriella Marisa Leonarduzzi
Prof. Giuseppe Poli

Tesi di dottorato

Ruolo dei prodotti di ossidazione del colesterolo nella patogenesi della malattia di Alzheimer

Attività di ricerca

Cholesterol oxidation products in the pathogenesis of Alzheimer's disease

Publications

Testa G., Di Meo C., Nardecchia S., Capitani D., Mannina L., Lamanna R., Barbetta A., Dentini M., Influence of dialkyne structure on the properties of new click-gels based on hyaluronic acid. Int. J. Pharm., 2009, 378, 86-92.

Leonarduzzi G., Testa G., Sottero B., Gamba P., Poli G. Design and development of nanovehicle-based delivery systems for preventative and therapeutic supplementation with flavonoids. Curr. Med. Chem., 2010, 17(1), 74-95.

Gamba P., Leonarduzzi G., Tamagno E., Guglielmotto M., Testa G., Sottero B., Gargiulo S., Biasi F., Mauro A., Viña J., Poli G. Interaction between 24-hydroxycholesterol, oxidative stress, and amyloid-β in amplifying neuronal damage in Alzheimer's disease: three partners in crime. Aging Cell., 2011, 10(3), 403-17.

Castello L., Maina M., Testa G., Cavallini G., Biasi F., Donati A., Leonarduzzi G., Bergamini E., Poli G., Chiarpotto E. Alternate-day fasting reverses the age-associated hypertrophy phenotype in rat heart by influencing the ERK and PI3K signaling pathways. Mech Ageing Dev., 2011, 132 (6-7), 305-14.

Leonarduzzi G., Sottero B., Testa G., Biasi F., Poli G. New insights into redox-modulated cell signaling. Curr. Pharm. Des., 2011, 17 (36), 3994-4006.

Gamba P., Testa G., Sottero B., Gargiulo S., Poli G., Leonarduzzi G. The link between altered cholesterol metabolism and Alzheimer’s disease. Ann. N. Y. Acad. Sci., 2012, 1259(1), 54-64.

Testa G., Gamba P., Di Scipio F., Sprio A.E., Salamone P., Gargiulo S., Sottero B., Biasi F., Berta G.N., Poli G., Leonarduzzi G. Potentiation of amyloid-β peptide neurotoxicity in human dental-pulp neuron-like cells by the membrane lipid peroxidation product 4-hydroxynonenal. Free Radic. Biol. Med., 2012, doi: 10.1016/j.freeradbiomed.2012.08.581. [Epub ahead of print].

Biasi F., Chiarpotto E., Sottero B., Maina M., Mascia C., Guina T., Gamba P., Gargiulo S., Testa G., Leonarduzzi G., Poli G. Evidence of cell damage induced by major components of a diet-compatible mixture of oxysterols in human colon cancer CaCo-2 cell line. Biochimie, 2012, doi: 10.1016/j.biochi.2012.10.011 [Epub ahead of print].

Gargiulo S., Gamba P., Testa G., Sottero B., Maina M., Guina T., Biasi F., Poli G., Leonarduzzi G. Molecular signaling involved in oxysterol-induced β1-integrin over-expression in human macrophages. Int. J. Mol. Sci., 2012, 13, 14278-14293; doi:10.3390/ijms131114278

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Proceedings (national and international meetings):

Testa G., Gargiulo S., Gamba P., Sottero B., Poli G., Leonarduzzi G. (2012). Involvement of oxysterols in atherosclerotic plaque instability. 16th Biennal Meeting of the Society for Free Radical Research International, London, September 6-9, London. Free Radic. Biol. Med. 2012, 53, 1(Suppl):S134, Abstract 0347.

Gamba P., Testa G., Gargiulo S., Guglielmotto M., Leonarduzzi G., Poli G. (2012). Interaction between oxidized lipids and amyloid-beta in amplifying neuronal damage in Alzheimer’s disease. 16th Biennal Meeting of the Society for Free Radical Research International, September 6-9, London. Free Radic. Biol. Med. 2012, 53, 1(Suppl):S244, Abstract HNE.O.9.

Maina M., Testa G., Biasi F., Leonarduzzi G., Poli G., Chiarpotto E. (2012). Alternate-day fasting reverses the age-associated hypertrophy phenotype in rat heart by influencing the ERK and PI3K signaling pathways. 16th Biennal Meeting of the Society for Free Radical Research International, September 6-9, London. Free Radic. Biol. Med. 2012, 53, 1(Suppl):S78, Abstract 0300.

Testa G., Gamba P., Tamagno E., Guglielmotto M., Gargiulo S., Sottero B., Leonarduzzi G., Poli G. (2012). Involvement of oxysterols in the pathogenesis of Alzheimer’s disease. 1st Joint Meeting of Pathology and Laboratory Diagnostics, September 12-15, Udine, Italy. Am. J. Pathol. 2012, 181(Suppl):S3, Abstract AGE11.

Gamba P., Testa G., Gargiulo S., Sottero B., Di Scipio F., Sprio A.E., Salamone P., Berta G.N., Leonarduzzi G., Poli G. (2012). Interaction between 4-hydroxynonenal and amyloid-beta in amplifying neuronal damage. 1st Joint Meeting of Pathology and Laboratory Diagnostics, September 12-15, Udine, Italy. Am. J. Pathol. 2012, 181(Suppl):S3, Abstract AGE12.

Gargiulo S., Gamba P., Sottero B., Testa G., Poli G., Leonarduzzi G. (2012). Role of oxysterols in the progression of atherosclerotic lesions. 1st Joint Meeting of Pathology and Laboratory Diagnostics, September 12-15, Udine, Italy. Am. J. Pathol. 2012, 181(Suppl):S7, Abstract CVBM7.


Communications (national and international meetings):

Maina M., Castello L., Testa G., Cavallini G., Bergamini E., Poli G., Chiarpotto E. (2010). Alternate-day fasting protects the rat heart against the age-related inflammation and fibrosis. Lipid oxidation, human diseases and aging, Torino, 16-18 Giugno 2010.

Testa G., Gamba P., Guglielmotto M., Tamagno E., Sottero B., Gargiulo S., Leonarduzzi G., Poli G. (2010). L’interazione tra 24-idrossicolesterolo e β-amiloide amplifica il danno neuronale nella malattia di Alzheimer. Aspetti molecolari del danno cellulare e tissutale - Riunione scientifica della Scuola Dianzani, Genova, 3-4 Dicembre 2010.

Maina M., Castello L., Testa G., Cavallini G., Biasi F., Leonarduzzi G., Donati A., Bergamini E., Poli G., Chiarpotto E. (2010). Il digiuno a giorni alterni modifica il fenotipo ipertrofico del miocardio nel ratto anziano agendo sulle vie di segnale ERK e PI3K. Aspetti molecolari del danno cellulare e tissutale - Riunione scientifica della Scuola Dianzani, Genova, 3-4 Dicembre 2010.

Leonarduzzi G., Biasi F., Gamba P., Gargiulo S., Mascia C., Testa G., Maina M., Poli G. (2011). Cholesterol oxidation products in the pathogenesis of human major chronic disease. International Symposium on Free Radical Research: Contribution to Medicine, Kyoto (Japan), 20-22 Gennaio 2011.

Leonarduzzi G., Gamba P., Testa G., Gargiulo S., Maina M., Biasi F., Poli G. (2011). Cholesterol oxidation in the pathogenesis of human major chronic disease. SFRR- Europe 2011 Meeting, Instanbul (Turkey), 7-10 Settembre 2011.

Leonarduzzi G., Gamba P., Testa G., Tamagno E., Guglielmotto M., Gargiulo S., Sottero B., Poli G. (2011). Implication of oxysterols in the neuronal damage of Alzheimer’s disease. 1st ENOR Symposium on Oxysterols and Related Sterols in Chemistry, Biology & Medicine, Roma, 22-24 Settembre 2011.

Leonarduzzi G., Gamba P., Testa G., Tamagno E., Guglielmotto M., Gargiulo S., Sottero B., Poli G. (2011). Interaction between 24-hydroxycholesterol and amyloid-β in amplifying neuronal damage in Alzheimer’s disease. Second International Conference on Enviromental Stressors in Biology and Medicine, Siena, 5-7 Ottobre 2011.

Gamba P., Testa G., Guglielmotto M., Tamagno E., Gargiulo S., Sottero B., Poli G., Leonarduzzi G. (2011). Interazione tra ossisteroli e β-amiloide nella malattia di Alzheimer. Nuovi orientamenti della patologia molecolare - Riunione scientifica della Scuola Dianzani, Sassari, 18-19 Novembre 2011.

Testa G., Gamba P., Tamagno E., Guglielmotto M., Gargiulo S., Sottero B., Leonarduzzi G., Poli G. (2012). Interaction between 24-hydroxycholesterol and amyloid-β in amplifying neuronal damage in Alzheimer disease. Oxidant and antioxidants in biology - Oxygen Club of California World Congress 2012, Alba (Cuneo), 20-23 Giugno 2012.

Maina M., Testa G., Biasi F., Leonarduzzi G., Poli G., Chiarpotto E. (2012). Alternate-day fasting reverses the age-associated hypertrophy phenotype in rat heart by influencing the ERK and PI3K signaling pathways. Oxidant and antioxidants in biology - Oxygen Club of California World Congress 2012, Alba (Cuneo), 20-23 Giugno 2012.

Gamba P., Testa G., Gargiulo S., Sottero B., Di Scipio F., Sprio A.E., Salamone P., Berta G.N., Leonarduzzi G., Poli G. (2012). Potentiation of amyloid-β peptide neurotoxicity by 4-hydroxynonenal and 24-hydroxycholesterol. Oxidant and antioxidants in biology - Oxygen Club of California World Congress 2012, Alba (Cuneo), 20-23 Giugno 2012.

Gargiulo S., Gamba P., Sottero B., Testa G., Poli G., Leonarduzzi G. (2012). Cholesterol oxidation products contribute to the imbalance between MMP-9 and TIMP-1/TIMP-2, in the atherosclerotic plaque. Oxidant and antioxidants in biology - Oxygen Club of California World Congress 2012, Alba (Cuneo), 20-23 Giugno 2012.

Gamba P., Testa G., Sottero B., Gargiulo S., Di Scipio F., Sprio A.E., Salamone P., Berta G.N., Leonarduzzi G., Poli G. (2012). Amyloid-β peptide neurotoxicity is potentiated by 4-hydroxynonenal and 24-hydroxycholesterol. 2nd ENOR Symposium on Oxysterols and Related Sterols in Chemistry, Biology & Medicine, Dijon (France), 20-21 Settembre 2012.

Gargiulo S., Gamba P., Sottero B., Testa G., Poli G., Leonarduzzi G., (2012). Plaque oxysterols induce imbalanced up-regulation of MMP-9 in macrophagic cells contributing to plaque vulnerability. 2nd ENOR Symposium on Oxysterols and Related Sterols in Chemistry, Biology & Medicine, Dijon (France), 20-21 Settembre 2012.

 

Ultimo aggiornamento: 18/11/2013 15:32
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