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Translational medicine in severe asthma

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Translational medicine in severe asthma

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Academic year 2023/2024

Teacher
Fabio Luigi Massimo Ricciardolo (Titolare del corso)
Teaching period
Da definire
Type
Course
Credits/Recognition
1
Delivery
A distanza
Language
Inglese
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Sommario del corso

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Course objectives

Bronchial asthma is a complex and heterogeneous chronic inflammatory disorder of the airways with variable airflow obstruction. According to the Global Burden Disease Study, about 240 million people suffer from asthma worldwide, and in 2016 it caused 495.000 deaths. A subset of asthmatic patients (10-20%) has uncontrolled respiratory symptoms, with half of them being affected by severe asthma. Based on ATS/ERS expert panel consensus, severe asthma is defined as asthma requiring treatment with guideline suggested medications for GINA steps 4–5 asthma (high dose inhaled corticosteroid and long-acting beta-agonist or leukotriene modifier/theophylline) for the previous year or systemic corticosteroid for ≥50% of the previous year to maintain disease control. Severe asthma, despite affecting only 5-10% of asthmatics, is responsible for a large part of asthmarelated national healthcare costs. 

Despite a growing number of personalized therapeutic options are becoming available for severe asthmatic patients some of them still remain unresponsive or with partly controlled disease. This is in part a consequence of the great heterogeneity of the disorder, to such a degree that it is possible to identify several clinical, biological and pathophysiological phenotypes each of them underlined by specific molecular mechanisms (endotypes), which are responsible of a highly variable response of patients to therapies. Over the last years, several studies on large cohorts were performed to identify phenotype clusters, with the aim of developing personalized therapies. 

This course is focused on the description of the complexity and heterogeneity of this respiratory disorder, aiming to innovation and personalized therapy based on the principles of precision medicine.

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Program

  • Definition 
  • Diagnosis
  • Pathophysiology
  • Phenotypes
  • Endotypes
  • Pharmacological Therapy and Biologics
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Course delivery

Slides with power-point presentation, reviews and original articles (suggested readings).

At least 2 lessons (2 hours per lesson) and 2 meetings with students showing presentations concerning other model of precision medicine with personalized therapy (e.g. lung cancer and others).

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Learning assessment methods

Final test examinations

Suggested readings and bibliography

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Notes

Mandatory Course third year

 

May 3, 2024
May 24, 2024

 

The course will be online
Registered Rand scholars will receive the link

Enroll
  • Open
    Enrollment opening date
    15/11/2023 at 12:00
    Enrollment closing date
    29/04/2024 at 12:00
    Oggetto:
    Last update: 26/01/2024 10:01
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