Selected research products

Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) Beyond Lipids: The Role in Oxidative Stress and Thrombosis
2022-01-01 Cammisotto V.; Baratta F.; Simeone P.G.; Barale C.; Lupia E.; Galardo G.; Santilli F.; Russo I.; Pignatelli P. https://iris.unito.it/handle/2318/1852158

Platelet Redox Imbalance in Hypercholesterolemia: A Big Problem for a Small Cell
2022-01-01 Morotti A.; Barale C.; Melchionda E.; Russo I. https://iris.unito.it/handle/2318/1877459

Clonal hematopoiesis by DNMT3A mutations as a common finding in idiopathic splanchnic vein thrombosis
2022-01-01 Carrà, Giovanna; Giugliano, Emilia; Camerlo, Sofia; Rosati, Giorgio; Branca, Enrica; Maffeo, Beatrice; Russo, Isabella; Piazza, Rocco; Cilloni, Daniela; Morotti, Alessandro https://iris.unito.it/handle/2318/1883284

PCSK9 Biology and Its Role in Atherothrombosis
2021-01-01 Barale, Cristina; Melchionda, Elena; Morotti, Alessandro; Russo, Isabella https://iris.unito.it/handle/2318/1790934

Proprotein convertase subtilisin kexin type 9 inhibitors reduce platelet activation modulating ox-LDL pathways
2021-01-01 Cammisotto V.; Baratta F.; Castellani V.; Bartimoccia S.; Nocella C.; D'erasmo L.; Cocomello N.; Barale C.; Scicali R.; Di Pino A.; Piro S.; Del Ben M.; Arca M.; Russo I.; Purrello F.; Carnevale R.; Violi F.; Pastori D.; Pignatelli P. https://iris.unito.it/handle/2318/1794742

Thrombopoietin contributes to enhanced platelet activation in patients with type 1 diabetes mellitus
2021-01-01 Bosco O.; Vizio B.; Gruden G.; Schiavello M.; Lorenzati B.; Cavallo-perin P.; Russo I.; Montrucchio G.; Lupia E. https://iris.unito.it/handle/2318/1793425

Prothrombotic phenotype in covid-19: Focus on platelets
2021-01-01 Barale C.; Melchionda E.; Morotti A.; Russo I. https://iris.unito.it/handle/2318/1829000

Influence of Cardiometabolic Risk Factors on Platelet Function
2020-01-01 Barale, Cristina; Russo, Isabella https://iris.unito.it/handle/2318/1725065

Ticagrelor Conditioning Effects Are Not Additive to Cardioprotection Induced by Direct NLRP3 Inflammasome Inhibition: Role of RISK, NLRP3, and Redox Cascades
2020-01-01 Penna, Claudia; Aragno, Manuela; Cento, Alessia Sofia; Femminò, Saveria; Russo, Isabella; Bello, Federica Dal; Chiazza, Fausto; Collotta, Debora; Alves, Gustavo Ferreira; Bertinaria, Massimo; Zicola, Elisa; Mercurio, Valentina; Medana, Claudio; Collino, Massimo; Pagliaro, Pasquale https://iris.unito.it/handle/2318/1748513

Platelet function and activation markers in primary hypercholesterolemia treated with anti-PCSK9 monoclonal antibody: A 12-month follow-up
2020-01-01 Barale C.; Bonomo K.; Frascaroli C.; Morotti A.; Guerrasio A.; Cavalot F.; Russo I. https://iris.unito.it/handle/2318/1719386

Association between high on-aspirin platelet reactivity and reduced superoxide dismutase activity in patients affected by type 2 diabetes mellitus or primary hypercholesterolemia
2020-01-01 Barale C.; Cavalot F.; Frascaroli C.; Bonomo K.; Morotti A.; Guerrasio A.; Russo I. https://iris.unito.it/handle/2318/1744812

Transferrin Saturation Inversely Correlates with Platelet Function
2019-01-01 Barale, Cristina; Senkeev, Rouslan; Napoli, Franca; De Gobbi, Marco; Guerrasio, Angelo; Morotti, Alessandro; Russo, Isabella https://iris.unito.it/handle/2318/1694927

Nuclear-cytoplasmic Shuttling in Chronic Myeloid Leukemia: Implications in Leukemia Maintenance and Therapy
2019-01-01 Carrà, Giovanna; Russo, Isabella; Guerrasio, Angelo; Morotti, Alessandro https://iris.unito.it/handle/2318/1719482

Hypercholesterolemia impairs the Glucagon-like peptide 1 action on platelets: Effects of a lipid-lowering treatment with simvastatin
2019-01-01 Barale C.; Frascaroli C.; Cavalot F.; Russo I. https://iris.unito.it/handle/2318/1706479

Simvastatin Effects on Inflammation and Platelet Activation Markers in Hypercholesterolemia
2018-01-01 Barale C.; Frascaroli C.; Senkeev R.; Cavalot F.; Russo I. https://iris.unito.it/handle/2318/1704316

Cardioprotective properties of human platelets are lost in uncontrolled diabetes mellitus: A study in isolated rat hearts
2018-01-01 Russo, Isabella; Femminò, Saveria; Barale, Cristina; Tullio, Francesca; Geuna, Stefano; Cavalot, Franco; Pagliaro, Pasquale; Penna, Claudia https://iris.unito.it/handle/2318/1671126

Glucagon-like peptide 1-related peptides increase nitric oxide effects to reduce platelet activation
2017-01-01 Barale, Cristina; Buracco, Simona; Cavalot, Franco; Frascaroli, Chiara; Guerrasio, Angelo; Russo, Isabella https://iris.unito.it/handle/2318/1657403

Effects of PCSK9 inhibitors on platelet function in adults with hypercholesterolemia
2017-01-01 Barale, Cristina; Bonomo, Katia; Noto, Fabio; Traversa, Monica; Cavalot, Franco; Iozzia, Mirko; Frascaroli, Chiara; Guerrasio, Angelo; Russo, Isabella https://iris.unito.it/handle/2318/1719605

Platelets, diabetes and myocardial ischemia/reperfusion injury
2017-01-01 Russo, Isabella; Penna, Claudia; Musso, Tiziana; Popara, Jasmin; Alloatti, Giuseppe; Cavalot, Franco; Pagliaro, Pasquale https://iris.unito.it/handle/2318/1641552

Transferrin Saturation and Its Association with Platelet Reactivity
2017-01-01 Russo, I; Barale, C; Napoli, F; De Gobbi, M; Guerrasio, A; Morotti, A https://iris.unito.it/handle/2318/1701125

Resistenza agli effetti del GLP-1 sulla risposta pastrinica nel diabete di tipo 2
2016-01-01 Barale C; Cavalot F; Frascaroli C; Guerrasio A; Russo I https://iris.unito.it/handle/2318/1601815

Platelets Protect Against Myocardial Injury, but Platelets From Patients With Type 2 Diabetes Mellitus (T2DM) Lose their Protective Properties
2016-01-01 Femminò, Saveria; Russo, Isabella; Cavalot, Franco; Barale, Cristina; Tullio, Francesca; Penna, Claudia; Pagliaro, Pasquale https://iris.unito.it/handle/2318/1621274

In type 2 diabetes mellitus the GLP-1 effects on platelets are impaired.
2016-01-01 Barale C; Frascaroli C; Cavalot F; Guerrasio A; Russo I https://iris.unito.it/handle/2318/1601444

Platelets poorly controlled type 2 diabetes subjects show an impaired ability to protect against the cardiac ischaemia/reperfusion injury
2016-01-01 Russo I; Femminò S; Barale C; Cavalot F; Tullio F; Penna C; Pagliaro P https://iris.unito.it/handle/2318/1601463

Impairment of GLP-1 effects in platelets from subjects affected by type 2 diabetes mellitus
2015-01-01 Barale C; Cavalot F; Frascaroli C; Mattiello L; Guerrasio A; Russo I https://iris.unito.it/handle/2318/1601819

Postprandial dysmetabolism and oxidative stress in type 2 diabetes: pathogenetic mechanisms and therapeutic strategies.
2015-01-01 Sottero, B; Gargiulo, S; Russo, I; Barale, C; Poli, G; Cavalot, F. https://iris.unito.it/handle/2318/1522208

Resistance to the GLP-1 effects on platelets in type 2 diabetes mellitus.
2015-01-01 Barale C; Cavalot F; Mattiello L; Guerrasio A; Russo I https://iris.unito.it/handle/2318/1521879

Resistance to the GLP-1 effects on platelets in type 2 diabetes mellitus
2015-01-01 Barale C; Cavalot F; Frascaroli C; Mattiello L; Guerrasio A; Russo I https://iris.unito.it/handle/2318/1601853

Leptin and vascular smooth muscle cells.
2014-01-01 Trovati M; Doronzo G; Barale C; Vaccheris C; Russo I; Cavalot F. https://iris.unito.it/handle/2318/154721

Glucagon-Like Peptide 1 reduces platelet activation induced by sodium arachidonate through the inhibition of PI-3K and MAPK pathways.
2014-01-01 Barale C; Frascaroli C; Mattiello L; Cavalot F; Guerrasio A; Russo I. https://iris.unito.it/handle/2318/155027

A novel truncated form of eNOS associates with altered vascular function.
2014-01-01 Galluccio E; Cassina L; Russo I; Gelmini F; Setola E; Rampoldi L; Citterio L; Rossodivita A; Kamami M; Colombo A; Alfieri O; Carini M; Bosi E; Trovati M; Piatti P; Monti LD; Casari G. https://iris.unito.it/handle/2318/155029

Glucagon-Like Peptide 1 reduces platelet activation: effects on PI-3K and MAPK pathways and oxidative stress in the presence of arachidonic acid.
2014-01-01 Barale C; Mattiello L; Cavalot F; Guerrasio A; Russo I. https://iris.unito.it/handle/2318/155026

Il GLP-1 aumenta l'effetto inibitorio dell'ossido nitrico sulle piastrine con meccanismo GLP-1R indipendente.
2014-01-01 Russo I; Barale C; Mattiello L; Cavalot F; Trovati M. https://iris.unito.it/handle/2318/155140

GLP-1 reduces the activation of PI3K and MAPK pathways and of oxidative stress induced by Na-arachidonate in platelets.
2014-01-01 Barale C; Mattiello L; Cavalot F; Guerrasio A; Russo I. https://iris.unito.it/handle/2318/155099

A short-term incubation with high glucose impairs VASP phosphorylation at serine 239 in response to the nitric oxide/cGMP pathway in vascular smooth muscle cells: role of oxidative stress.
2014-01-01 Russo I;Viretto M;Doronzo G;Barale C;Mattiello L;Anfossi G;Trovati M https://iris.unito.it/handle/2318/154565

GLP-1 influences the inhibitory effects of nitric oxide on platelets.
2013-01-01 Russo I; Barale C; Mattiello L; Cavalot F; Trovati M. https://iris.unito.it/handle/2318/151742

An intensive control of blood glucose improves platelet sensitivity to aspirin in type 2 diabetes mellitus.
2013-01-01 Russo I; Barale C; Chirio M; Secchi M; Viretto M; Doronzo G; Mattiello L; Pagliarino A; Cavalot F; Anfossi G; Trovati M. https://iris.unito.it/handle/2318/151744

GLP-1 and liraglutide increase the platelet inhibitory effects of nitric oxide.
2013-01-01 Russo I; Barale C; Mattiello L; Cavalot F; Trovati M. https://iris.unito.it/handle/2318/151743

Il miglioramento del controllo glicemico riduce la resistenza piastrinica all'aspirina nei pazienti affetti da diabete di tipo 2
2013-01-01 Russo, I; Barale, C; Chirio, M; Secchi, M; Viretto, M; Doronzo, G; Mattiello, L; Pagliarino, A; Valle, M; Vaccheris, C; Cavalot, F; Anfossi, G; Trovati, M https://iris.unito.it/handle/2318/1521881

Oleic acid increases synthesis and secretion of VEGF in rat vascular smooth muscle cells: role of oxidative stress and impairment in obesity.
2013-01-01 Doronzo G; Viretto M; Barale C; Russo I; Mattiello L; Anfossi G; Trovati M. https://iris.unito.it/handle/2318/140867

Effects of high glucose on vascular endothelial growth factor synthesis and secretion in aortic vascular smooth muscle cells from obese and lean zucker rats.
2012-01-01 Doronzo G; Viretto M; Russo I; Mattiello L; Anfossi G; Trovati M. https://iris.unito.it/handle/2318/119499

Non-HDL cholesterol is a determinant of aspirin-resistance in type 2 diabetes mellitus.
2012-01-01 Russo I; Barale C; Chirio M; Secchi M; Mattiello L; Pagliarino A; Vaccheris C; Cavalot F; Doronzo G; Anfossi G; Trovati M. https://iris.unito.it/handle/2318/151748

Acido oleico e regolazione del VEGF in cellule muscolari lisce vascolari aortiche in condizioni di insulino-sensibilità e insulino-resistenza.
2012-01-01 Doronzo G; Viretto M; Russo I; Mattiello L; Barale C; Vaccheris C; Anfossi G; Trovati M. https://iris.unito.it/handle/2318/151747

Influenza dell’alto glucosio sull’aggregazione piastrinica in soggetti aspirino-trattati.
2012-01-01 Russo I; Frascaroli C; Viretto M; Barale C; Mattiello L; Doronzo G; Vaccheris C; Trovati M; Anfossi G. https://iris.unito.it/handle/2318/151746

High Glucose Inhibits the Aspirin-Induced Activation of the Nitric Oxide/cGMP/cGMP-Dependent Protein Kinase Pathway and Does Not Affect the Aspirin-Induced Inhibition of Thromboxane Synthesis in Human Platelets.
2012-01-01 Russo I; Viretto M; Barale C; Mattiello L; Doronzo G; Pagliarino A; Cavalot F; Trovati M; Anfossi G. https://iris.unito.it/handle/2318/118245

L'acido oleico incrementa trascrizione, sintesi e secrezione del VEGF in cellule muscolari lisce vascolari aortiche: ridotto effetto in condizioni di insulino-resistenza
2012-01-01 Doronzo G; Viretto M; Russo I; Mattiello L; Barale C; Anfossi G; Vaccheris C; Trovati M https://iris.unito.it/handle/2318/1521889

A short-term improvement of blood glucose control increases aspirin sensitivity in aspirin-resistant type 2 diabetic men.
2012-01-01 Russo I; Barale C; Chirio M; Secchi M; Viretto M; Doronzo G; Mattiello L; Pagliarino A; Cavalot F; Valle M; Anfossi G; Trovati M. https://iris.unito.it/handle/2318/151745

The prothrombotic tendency in metabolic syndrome: focus on the potential mechanisms involved in impaired haemostasis and fibrinolytic balance.
2012-01-01 Russo I https://iris.unito.it/handle/2318/143290

High glucose reduces the anti-aggregating effect of aspirin by impairing the aspirin-induced activation of the nitric oxide/cGMP/PKG pathway.
2011-01-01 Russo I; Barale C; Mattiello L; Viretto M; Doronzo G; Ceraolo E; Trovati M; Anfossi G https://iris.unito.it/handle/2318/1508465

Nitric oxide activates PI3-K and MAPK signalling pathways in human and rat vascular smooth muscle cells: influence of insulin resistance and oxidative stress.
2011-01-01 Doronzo G; Viretto M; Russo I; Mattiello L; Di Martino L; Cavalot F; Anfossi G; Trovati M. https://iris.unito.it/handle/2318/131175

High glucose reduces the anti-aggreganting effect of aspirin by impairing the aspirin-induced activation of the nitric oxide/cGMP/PKG pathway.
2011-01-01 Russo I; Barale C; Mattiello L; Viretto M; Doronzo G; Ceraolo E; Trovati M; Anfossi G https://iris.unito.it/handle/2318/1521894

Aspirin resistant subjects present a proinflammatory milieu with an increased oxidative stress: in these conditions, high glucose fails to influence platelet responses to agonists.
2011-01-01 Russo I; Frascaroli C; Mattiello L; Viretto M; Barale C; Doronzo G; Di Martino L; Trovati M; Anfossi G. https://iris.unito.it/handle/2318/151750

Influence of oleic acid on vascular endothelial growth factor synthesis and secretion in aortic vascular smooth muscle cells: signalling molecules involved and role of insulin resistance
2011-01-01 Doronzo G; Viretto M; Russo I; Mattiello L; Barale C; Ceraolo E; Anfossi G; Trovati M https://iris.unito.it/handle/2318/1521893

Role of NMDA receptor in homocysteine-induced activation of Mitogen-Activated Protein Kinase and Phosphatidyl Inositol 3-Kinase pathways in cultured human vascular smooth muscle cells
2010-01-01 Doronzo G; Russo I; Del Mese P; Viretto M; Mattiello L; Trovati M; Anfossi G. https://iris.unito.it/handle/2318/65014

The Cardiovascular Effects of Metformin: Further Reasons to Consider an Old Drug as a Cornerstone in the Therapy of Type 2 Diabetes Mellitus
2010-01-01 Anfossi G; Russo I; Bonomo K; Trovati M. https://iris.unito.it/handle/2318/65067

In Central Obesity, Weight Loss Restores Platelet Sensitivity to Nitric Oxide and Prostacyclin
2010-01-01 Russo I; Traversa M; Bonomo K; De Salve A; Mattiello L; Del Mese P; Doronzo G; Cavalot F; Trovati M; Anfossi G. https://iris.unito.it/handle/2318/65015

Adipocytokines in atherothrombosis: focus on platelets and vascular smooth muscle cells.
2010-01-01 Anfossi G; Russo I; Doronzo G; Pomero A; Trovati M. https://iris.unito.it/handle/2318/129284

Contribution of insulin resistance to vascular dysfunction
2009-01-01 Anfossi G; Russo I; Doronzo G; Trovati M. https://iris.unito.it/handle/2318/64419

Platelet dysfunction in central obesity
2009-01-01 Anfossi G; Russo I; Trovati M. https://iris.unito.it/handle/2318/65054

Resistance to the nitric oxide/cyclic guanosine 5'-monophosphate/protein kinase G pathway in vascular smooth muscle cells from the obese Zucker rat, a classical animal model of insulin resistance: role of oxidative stress
2008-01-01 Russo I; Del Mese P; Doronzo G; Mattiello L; Viretto M; Bosia A; Anfossi G; Trovati M https://iris.unito.it/handle/2318/56054

Sodium azide, a bacteriostatic preservative contained in commercially available laboratory reagents, influences the responses of human platelets via the cGMP/PKG/VASP pathway.
2008-01-01 RUSSO I; DEL MESE P; VIRETTO M; DORONZO G; MATTIELLO L; TROVATI M.; ANFOSSI G https://iris.unito.it/handle/2318/64563

Resistance to aspirin and thienopyridines in diabetes mellitus and metabolic syndrome
2008-01-01 Anfossi G; Russo I; Trovati M. https://iris.unito.it/handle/2318/57007

Relevance of the vascular effects of insulin in the rationale of its therapeutical use
2007-01-01 Anfossi G; Russo I; Doronzo G; Trovati M. https://iris.unito.it/handle/2318/60138

Platelet resistance to the antiaggregatory cyclic nucleotides in central obesity involves reduced phosphorylation of vasodilator-stimulated phosphoprotein
2007-01-01 RUSSO I; DEL MESE P; DORONZO G; DE SALVE A; SECCHI M; TROVATI M.; ANFOSSI G https://iris.unito.it/handle/2318/64386

Insulin activates hypoxia-inducible factor-1alpha in human and rat vascular smooth muscle cells via phosphatidylinositol-3 kinase and mitogen-activated protein kinase pathways: impairment in insulin resistance owing to defects in insulin signalling
2006-01-01 DORONZO G; RUSSO I; MATTIELLO L; RIGANTI C; ANFOSSI G; TROVATI M https://iris.unito.it/handle/2318/39571

Platelet resistance to the anti-aggregating agents in the insulin resistant states.
2006-01-01 ANFOSSI G; RUSSO I; M. TROVATI https://iris.unito.it/handle/2318/28380

Sodium azide in commercially available C-reactive protein preparations does not influence matrix metalloproteinase-2 synthesis and release in cultured human aortic vascular smooth muscle cells
2006-01-01 DORONZO G; RUSSO I; TROVATI M; ANFOSSI G. https://iris.unito.it/handle/2318/1075

Homocysteine rapidly increases matrix metalloproteinase-2 expression and activity in cultured human vascular smooth muscle cells. Role of phosphatidyl inositol 3-kinase and mitogen activated protein kinase pathways
2005-01-01 DORONZO G; RUSSO I; MATTIELLO L; TROVATI M; ANFOSSI G. https://iris.unito.it/handle/2318/1290

High glucose rapidly activates the nitric oxide/cyclic nucleotide pathway in human platelets via an osmotic mechanism
2005-01-01 MASSUCCO P; MATTIELLO L; RUSSO I; TRAVERSA M; DORONZO G; ANFOSSI G; TROVATI M https://iris.unito.it/handle/2318/1364

C-reactive protein increases matrix metalloproteinase-2 expression and activity in cultured human vascular smooth muscle cells
2005-01-01 DORONZO G; RUSSO I; MATTIELLO L; TROVATI M; ANFOSSI G. https://iris.unito.it/handle/2318/1410

The activity of constitutive nitric oxide synthase is increased by the pathway cAMP/cAMP-activated protein kinase in human platelets. New insights into the antiaggregating effects of cAMP-elevating agents
2004-01-01 RUSSO I; DORONZO G; MATTIELLO L; DE SALVE A; TROVATI M; ANFOSSI G. https://iris.unito.it/handle/2318/22034

Insulin activates vascular endothelial growth factor in vascular smooth muscle cells: influence of nitric oxide and of insulin resistance
2004-01-01 DORONZO G.; RUSSO I.; MATTIELLO L.; ANFOSSI G.; BOSIA A.; TROVATI M. https://iris.unito.it/handle/2318/40908

Impaired synthesis and action of antiaggregating cyclic nucleotides in platelets from obese subjects: possible role in platelet hyperactivation in obesity
2004-01-01 ANFOSSI G.; RUSSO I.; MASSUCCO P.; MATTIELLO L.; DORONZO G.; DE SALVE A.; TROVATI M. https://iris.unito.it/handle/2318/23470

Comparison between the effects of the rapid recombinant insulin analog LYSPRO (Lys B28, Pro B29) and those of human regular insulin on platelet cyclic nucleotides and aggregation
2003-01-01 RUSSO I; MASSUCCO P; MASSUCCO P.; CAVALOT F.; ANFOSSI G.; TROVATI M. https://iris.unito.it/handle/2318/1363

Insulin stimulates glucose transport via nitric oxide/cyclic GMP pathway in human vascular smooth muscle cells
2003-01-01 BERGANDI L; SILVAGNO F; RUSSO I; RIGANTI C; ANFOSSI G; ALDIERI E; GHIGO D; TROVATI M; BOSIA A https://iris.unito.it/handle/2318/5757

Platelet resistance to the antiaggregating effect of N-acetyl-L-cysteine in obese, insulin-resistant subjects.
2003-01-01 G. ANFOSSI; RUSSO I.; MASSUCCO P.; MATTIELLO L.; TROVATI M. https://iris.unito.it/handle/2318/22024

Insulin influences the nitric oxide cyclic nucleotide pathway in cultured human smooth muscle cells from corpus cavernosum by rapidly activating a constitutive nitric oxide synthase.
2002-01-01 ANFOSSI G ;MASSUCCO P ;MATTIELLO L ;BALBO A ;RUSSO I ;DORONZO G ;ROLLE L ;GHIGO D ;FONTANA D ;BOSIA A ;TROVATI M https://iris.unito.it/handle/2318/38043

Adenosine increases human platelet levels of cGMP through nitric oxide: possible role in its antiaggregating effect.
2002-01-01 G. ANFOSSI; RUSSO I.; MASSUCCO P.; MATTIELLO L.; CAVALOT F.; BALBO A.; TROVATI M. https://iris.unito.it/handle/2318/1409

Comparison between the effects of the rapid recombinant insulin analog aspart and those of human regular insulin on platelet cyclic nucleotides and aggregation.
2002-01-01 RUSSO I; MASSUCCO P; MATTIELLO L.; CAVALOT F.; G. ANFOSSI; TROVATI M. https://iris.unito.it/handle/2318/1456

Catecholamines, via beta-adrenoceptors, increase intracellular concentrations of 3',5'-cyclic guanosine monophosphate (cGMP) through nitric oxide in human platelets.
2002-01-01 ANFOSSI G; RUSSO I; MASSUCCO P; MATTIELLO L; M. TROVATI https://iris.unito.it/handle/2318/1665

N-acetyl-L-cysteine exerts direct anti-aggregating effect on human platelets.
2001-01-01 ANFOSSI G; RUSSO I; MASSUCCO P; MATTIELLO L; CAVALOT F; M. TROVATI https://iris.unito.it/handle/2318/22035

Studies on inhibition of human platelet function by sodium nitroprusside. Kinetic evaluation of the effect on aggregation and cyclic nucleotide content.
2001-01-01 G. ANFOSSI; RUSSO I.; MASSUCCO P.; MATTIELLO L.; BALBO A.; CAVALOT F.; TROVATI M. https://iris.unito.it/handle/2318/23436

L-arginine modulates aggregation and intracellular cyclic 3',5'-guanosine monophosphate levels in human platelets: direct effect and interplay with antioxidative agent.
1999-01-01 G. ANFOSSI; RUSSO I.; MASSUCCO P.; MATTIELLO L.; PERNA P.; TASSONE F.; TROVATI M. https://iris.unito.it/handle/2318/22045

Influence of protamine on adhesion, chemotaxis and proliferation of human vascular smooth muscle cells.
1997-01-01 CAVALOT F; RUSSO I; MATTIELLO L; G. ANFOSSI; MASSUCCO P; MULARONI E; HAHN AW; TROVATI M. https://iris.unito.it/handle/2318/21656

Nonenzymatic glycation of fibronectin impairs adhesive and proliferative properties of human vascular smooth muscle cells.
1996-01-01 CAVALOT F; G. ANFOSSI; RUSSO I; MULARONI E; MASSUCCO P; MATTIELLO L; BURZACCA S; HAHN AW; TROVATI M. https://iris.unito.it/handle/2318/1319

Studies on in vitro effect of picotamide on human platelet aggregation in platelet-rich plasma and whole blood.
1995-01-01 G. ANFOSSI; PARISI S; RUSSO I; MULARONI EM; MASSUCCO P; CAVALOT F; MATTIELLO L; TROVATI M. https://iris.unito.it/handle/2318/23092

Insulin stimulates the polymorphonuclear leukocyte chemokinesis.
1993-01-01 CAVALOT F; ANFOSSI G; RUSSO I; MULARONI E; MASSUCCO P; BURZACCA S; MATTIELLO L; M. TROVATI https://iris.unito.it/handle/2318/21655

Insulin, at physiological concentrations, enhances the polymorphonuclear leukocyte chemotactic properties.
1992-01-01 CAVALOT F; ANFOSSI G; RUSSO I; MULARONI E; MASSUCCO P; BURZACCA S; MATTIELLO L; M. TROVATI https://iris.unito.it/handle/2318/21654

Courses

• ASPETTI BIOCHIMICI DELLA NUTRIZIONE UMANA (INT0710B)
  Corso di laurea magistrale in Scienze degli Alimenti e della Nutrizione Umana
• ASPETTI GENETICI, BIOCHIMICI E PATOLOGICI DELLA NUTRIZIONE UMANA (INT0710)
  Corso di laurea magistrale in Scienze degli Alimenti e della Nutrizione Umana
• Biochimica clinica 4 (MED2880C)
  Corso di Laurea in Tecniche di Laboratorio Biomedico - Cuneo
• I. BIOCHIMICA CLINICA II (MED2880)
  Corso di Laurea in Tecniche di Laboratorio Biomedico - Cuneo
• Platelet dysfunction in atherothrombotic diseases
  PhD Programme in Experimental Medicine and Therapy - Dottorato in Medicina e Terapia Sperimentale

Research topics

Research topics

Her research activity is concerned with pathophysiological mechanisms implicated in atherothrombosis in metabolic diseases, with an approach that ranges from the biochemistry of macromolecules and their interactions, to molecular and cellular biology. Specifically, she has focused the attention on functions and impairments of peculiar biochemical processes  in vascular  cells in condition of obesity, insulin-resistance, diabetes, and hypercholesterolemia. The main topics of her research activity can be summarized as follows: (i) insulin effects on vascular smooth muscle cells, platelets, and neutrophils; (ii) role of endogenous synthesis of nitric oxide on platelet function and vascular smooth muscle cells (iii) platelet response to pharmacological substances (i.e. nitric oxide donors, insulin, aspirin, PCSK9 inhibitors, GLP-1 agonists); (iii) studies on platelet dysfunction before and after pharmacological/dietary intervention  in patients affected by diabetes,  obesity or dyslipidemia.

Academic bodies

• Consiglio di Dipartimento - Dipartimento di Scienze Cliniche e Biologiche