PhD Programme in Experimental Medicine and Therapy - Dottorato in Medicina e Terapia Sperimentale

Cardioprotection

Academic year 2020/2021

Sommario del corso

• Course objectives
• Course delivery
• Learning assessment methods
• Program
• Suggested textbooks and readings
• Notes
• Teaching tools

Course objectives

To learn the up-to-date concepts about cardioprotection mechanisms and procedures

Course delivery

• Teaching tools: Power-point presentation, review and research articles on the topic
• Methods: Frontal lecture and student presentations.

Learning assessment methods

Short essay on one of the topic treated during the lectures:

• Metabolic syndrome and cardioprotective manoeuvres
• Inflammation and cardioprotective manouvres
• Gender and response to cardioprotective manouvres
• Redox system and cardiac ischemia reperfusion injuries
• Novel cardioprotective approach
• Remote conditioning
• Antiplatelets and cardioprotection
• Molecular mechanism of mitochondrial defense in the cardioprotection
• Cardioprotection with beta-blockers
• G protein-coupled receptor (GPCR) and cardioprotection
• Coronary circulation in cardioprotection

Reports must have the following characteristics: at least 5 pages and two figures, bibliography.

Program

• Mechanisms of myocardial/ischemia reperfusion. Procedures and mechanisms of preconditioning, perconditioning and postconditioning. First and second window of protection. Remote conditioning.
• Role of comorbidities. Parallelism with exercise.

• Penna C, Andreadou I, Aragno M, Beauloye C, Bertrand L, Lazou A, Falcão-Pires I, Bell R,Zuurbier CJ, Pagliaro P, Hausenloy DJ. Effect of hyperglycaemia and diabetes on acute myocardial ischaemia-reperfusion injury and cardioprotection by ischaemic conditioning protocols. Br J Pharmacol. 2020 Jan 27.
  doi: 10.1111/bph.14993. [Epub ahead of print] Review. PubMed PMID: 31985828.
• Femminò S, Pagliaro P, Penna C. Obesity and cardioprotection. Curr Med Chem. 2019 Mar 24.
  doi:10.2174/0929867326666190325094453. [Epub ahead of print] PubMed PMID: 30907304.
• Davidson SM, Andreadou I, Barile L, Birnbaum Y, Cabrera-Fuentes HA, Cohen MV, Downey JM, Girao H, Pagliaro P, Penna C, Pernow J, Preissner KT, Ferdinandy P. Circulating blood cells and extracellular vesicles in acute cardioprotection. Cardiovasc Res. 2019 Jun 1;115(7):1156-1166.
  doi: 10.1093/cvr/cvy314. PubMed PMID: 30590395; PubMed Central PMCID: PMC6529916.
• Zuurbier CJ, Abbate A, Cabrera-Fuentes HA, Cohen MV, Collino M, De Kleijn DPV, Downey JM, Pagliaro P, Preissner KT, Takahashi M, Davidson SM. Innate immunity as a target for acute cardioprotection. Cardiovasc Res. 2019 Jun 1;115(7):1131-1142.
  doi: 10.1093/cvr/cvy304. PubMed PMID: 30576455; PubMed Central PMCID: PMC6529915.
• Bøtker HE, Hausenloy D, Andreadou I, Antonucci S, Boengler K, Davidson SM, Deshwal S, Devaux Y, Di Lisa F, Di Sante M, Efentakis P, Femminò S, García-Dorado D, Giricz Z, Ibanez B, Iliodromitis E, Kaludercic N, Kleinbongard P, Neuhäuser M, Ovize M, Pagliaro P, Rahbek- Schmidt M, Ruiz-Meana M, Schlüter KD, Schulz R, Skyschally A, Wilder C, Yellon DM, Ferdinandy P, Heusch G. Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection. Basic Res Cardiol. 2018 Aug 17;113(5):39.
  doi:10.1007/s00395-018-0696-8. Review. PubMed PMID: 30120595; PubMed Central PMCID: PMC6105267.
• Penna C, Alloatti G, Crisafulli A. Mechanisms Involved in Cardioprotection Induced by Physical Exercise. Antioxid Redox Signal. 2020 Jan 30.
  doi: 10.1089/ars.2019.8009. [Epub ahead of print] PubMed PMID: 31892282.

Note

Strongly recommended course for XXXV/XXXVI/XXXVII Cycle Second-Year Students

• Teaching materials
• Exams and finals
• Go to Moodle
• Visit the forums