Vai al contenuto principale





Academic year 2023/2024

Pasquale Pagliaro (Titolare del corso)
Teaching period
Da definire
Course disciplinary sector (SSD)
BIO/09 - physiology

Sommario del corso


Course objectives

To learn the up-to-date concepts about cardioprotection mechanisms and procedures



  • Mechanisms of myocardial/ischemia reperfusion. Procedures and mechanisms of preconditioning, perconditioning and postconditioning. First and second window of protection. Remote conditioning.
  • Role of comorbidities. Parallelism with exercise.

Course delivery

  • Teaching tools: Power-point presentation, review and research articles on the topic
  • Methods: Frontal lecture and student presentations.

Learning assessment methods

Short essay on one of the topic treated during the lectures:

  • Metabolic syndrome and cardioprotective manoeuvres
  • Inflammation and cardioprotective manouvres
  • Gender and response to cardioprotective manouvres
  • Redox system and cardiac ischemia reperfusion injuries
  • Novel cardioprotective approach
  • Remote conditioning
  • Antiplatelets and cardioprotection
  • Molecular mechanism of mitochondrial defense in the cardioprotection
  • Cardioprotection with beta-blockers
  • G protein-coupled receptor (GPCR) and cardioprotection
  • Coronary circulation in cardioprotection

Reports must have the following characteristics: at least 5 pages and two figures, bibliography.

Suggested readings and bibliography


  • Penna C, Andreadou I, Aragno M, Beauloye C, Bertrand L, Lazou A, Falcão-Pires I, Bell R,Zuurbier CJ, Pagliaro P, Hausenloy DJ. Effect of hyperglycaemia and diabetes on acute myocardial ischaemia-reperfusion injury and cardioprotection by ischaemic conditioning protocols. Br J Pharmacol. 2020 Jan 27.
    doi: 10.1111/bph.14993. [Epub ahead of print] Review. PubMed PMID: 31985828.
  • Femminò S, Pagliaro P, Penna C. Obesity and cardioprotection. Curr Med Chem. 2019 Mar 24.
    doi:10.2174/0929867326666190325094453. [Epub ahead of print] PubMed PMID: 30907304.
  • Davidson SM, Andreadou I, Barile L, Birnbaum Y, Cabrera-Fuentes HA, Cohen MV, Downey JM, Girao H, Pagliaro P, Penna C, Pernow J, Preissner KT, Ferdinandy P. Circulating blood cells and extracellular vesicles in acute cardioprotection. Cardiovasc Res. 2019 Jun 1;115(7):1156-1166.
    doi: 10.1093/cvr/cvy314. PubMed PMID: 30590395; PubMed Central PMCID: PMC6529916.
  • Zuurbier CJ, Abbate A, Cabrera-Fuentes HA, Cohen MV, Collino M, De Kleijn DPV, Downey JM, Pagliaro P, Preissner KT, Takahashi M, Davidson SM. Innate immunity as a target for acute cardioprotection. Cardiovasc Res. 2019 Jun 1;115(7):1131-1142.
    doi: 10.1093/cvr/cvy304. PubMed PMID: 30576455; PubMed Central PMCID: PMC6529915.
  • Bøtker HE, Hausenloy D, Andreadou I, Antonucci S, Boengler K, Davidson SM, Deshwal S, Devaux Y, Di Lisa F, Di Sante M, Efentakis P, Femminò S, García-Dorado D, Giricz Z, Ibanez B, Iliodromitis E, Kaludercic N, Kleinbongard P, Neuhäuser M, Ovize M, Pagliaro P, Rahbek- Schmidt M, Ruiz-Meana M, Schlüter KD, Schulz R, Skyschally A, Wilder C, Yellon DM, Ferdinandy P, Heusch G. Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection. Basic Res Cardiol. 2018 Aug 17;113(5):39.
    doi:10.1007/s00395-018-0696-8. Review. PubMed PMID: 30120595; PubMed Central PMCID: PMC6105267.
  • Penna C, Alloatti G, Crisafulli A. Mechanisms Involved in Cardioprotection Induced by Physical Exercise. Antioxid Redox Signal. 2020 Jan 30.
    doi: 10.1089/ars.2019.8009. [Epub ahead of print] PubMed PMID: 31892282.



Courses strongly recommended for the second year

  • Open
    Enrollment opening date
    15/11/2022 at 12:00
    Enrollment closing date
    31/07/2024 at 12:00
    Last update: 23/11/2023 10:44
    Non cliccare qui!